苯丙胺类兴奋剂所致精神障碍的临床诊治问题

Diagnosis and clinical management of amphetamine-induced psychosis

近年国内苯丙胺类兴奋剂滥用日益严重,苯丙胺类兴奋剂所致精神障碍成为精神科临床的一个重要挑战。本文介绍了苯丙胺类兴奋剂所致精神障碍的分子遗传及病理机制方面的研究,并对其临床表现、诊断及药物治疗问题进行了综述,同时提出了未来研究的问题及方向。作者期望本文有助于深化读者对苯丙胺类兴奋剂所致精神障碍的了解及临床治疗疗效的提高。

Psychosis induced by amphetamine-type stimulants （ATS） has become an important clinical challenge in psychiatric practice in China over recent years because of the rapid increase in the prevalence of ATS abuse. The authors introduce research on the genetic and pathological mechanisms underling ATS-induced psychosis and summarize findings on its clinical features, diagnosis and pharmacological treatment. They also discuss issues that need to be addressed in future research to increase understanding of ATS-induced psychosis and to improve the effectiveness of the clinical management of this condition.