雌激素保护期成年截瘫女性血脂代谢研究

Serum Lipid Profile in Chinese Premenopausal Women with Chronic Paraplegia

目的通过流行病学调查了解绝经前截瘫女性血脂水平,探讨截瘫致缺乏运动对雌激素保护期女性血脂代谢的影响。方法 2004~2009年中国康复研究中心截瘫女性住院患者183例入院时行血脂状态调查。血脂观察指标：甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。结果截瘫女性TG、TC水平显著高于女性全国平均水平,分别达到1.44mmol/L和4.45 mmol/L;HDL、LDL平均水平均与女性全国平均水平无显著性差异。年龄与TG（r=0.158,P〈0.05）、TC（r=0.271,P〈0.01）、LDL（r=0.207,P〈0.01）呈正相关;与HDL无显著性相关。总体血脂异常发生率60%,依次为低HDL（33%）、高TC（25%）、高TG（24%）、高LDL（21%）。结论在雌激素保护作用下,HDL代谢受缺乏运动的影响较小,但TG、TC代谢仍有一定程度紊乱,心血管疾病风险增加。

Objective To investigate the characteristics of serum lipids levels in young women with paraplegia in sedantary lifestyles.Methods 183 female paraplegics who admitted in China Rehabilitation Research Centre（CRRC） from Jan 2004 to Dec 2009 were investigated.Lipid profiles included triglyceride（TG）,total cholesterol（TC）,low density lipoprotein（LDL）,and high-density lipoprotein（HDL）.Results Female paraplegics showed higher mean TG and TC levels than mean levels of Chinese females（TG 1.44 mmol/L vs.1.24 mmol/ L;TC 4.45 mmol/L vs.4.30 mmol/L）.But no difference was found in HDL and LDL levels.TG,TC and LDL levels were correlated positively to age（r=0.158,P〈0.05;r=0.271,P0.01;r=0.207,P0.01,respectively）,but HDL showed no correlation to age.Prevalence of dislipidemia was 60%,including low HDL（33%）,high TC（25%）,high TG（24%）,and high LDL（21%）.Conclusion Lack of exercise may result in some dyslipidemia and increase cardiovascular risks in women who are under estrogen protection.