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PI3K/Akt信号通路在肿瘤发展和治疗中的作用 被引量：15

Role of PI3K/Akt signaling pathway in tumor progress and treatment
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摘要 目前发现有多条信号网络通路参与调控肿瘤生成、增殖、凋亡等分子机制,PI3K/Akt是其中比较重要的一条信号传导途径,该通路与肿瘤的发生发展密切相关。该文就PI3K/Akt信号通路的结构组成与调控肿瘤机制进行阐述,并介绍了其在临床中的应用与前景。 At present,multiple signaling networks were found in regulating the molecular mechanism of tumorigenesis,proliferation and apoptosis.PI3K/Akt is one of the important signaling pathways,which is correlative with the genesis and progress of malignant tumors.Therefore,this paper sets forth the composition and regulating tumor mechanism of PI3K/Akt signaling pathway,meanwhile,elucidates its clinical application and prospects.
作者 张立功 钱军
机构地区 蚌埠医学院第一附属医院肿瘤外三科
出处 《安徽医药》 CAS 2012年第2期149-151,共3页 Anhui Medical and Pharmaceutical Journal
关键词 磷脂酰肌醇3-激酶 蛋白激酶B 信号转导通路 肿瘤 phosphoinositide 3-kinase protein kinase B signaling pathway neoplasms
分类号 R730.5 [医药卫生—肿瘤]
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参考文献28

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  • 2Yuan TL.PI3K pathway alterations in cancer:variations on a theme[J].Oncogene,2008,27(41):5497-510.
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同被引文献165

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安徽医药
2012年 第2期

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