现代色谱技术在临床药理学研究中的应用

Application of chromatography technology in clinical pharmacology

色谱技术作为一种分析方法,是临床药理学的重要研究手段之一。临床药理学是研究药物在体内作用规律和人体与药物相互作用的一门交叉学科,本文从药动学、生物等效性、药物体内转运及代谢途径、药物反应的个体及种族差异、药物相互作用、药物疗效和浓度检测及体内活性物质检测的研究等方面探讨色谱技术在临床药理学研究中的应用进展。

Chromatography technology, an analysis method, is one of the major research methods of clinical pharmacology. Chnical pharmacology is an inter discipline developed over several decades, which research the regularity of drug effect in human body and the interaction of drug and human body. This article summarized the application of chromatography technology in clinical pharmacology： pharmacokinetics, bioequivalence, drug transport and metabolism pathway, drug responses individual difference and ethnic difference, drug - drug interaction and therapeutic drug monitoring.