甲烷磺酸铜催化合成丁酸异戊酯的性能研究

Catalytic synthesis of isoamyl butyrate with copper methanesulfonate

以甲烷磺酸铜作为合成丁酸异戊酯的催化剂,考察了催化剂用量、反应时间、醇酸物质的量比对酯化率的影响。实验表明,丁酸0.167mol,醇酸物质的量比1.2∶1,甲烷磺酸铜用量0.125%(基于丁酸的物质的量分数,下同),反应时间1.5～2.0h,环己烷5mL作带水剂,在回流温度下酯化率可达97.8%;与CuSO4.5H2O等其他几种Lewis酸相比,甲烷磺酸铜具有较高的催化活性,反应后易与产物分离,催化剂重复使用8次,酯化率仍达到93.0%以上。

Copper methanesulfonate is used as catalyst in esterification of isoamyl alcohol with butyric acid, the amount of catalyst, reaction time and the ratio of alcohol to acid, which effected the reaction have been investigated. Under the following conditions： 0. 167 tool butyric acid, 1.2：1 molar ratio of isoamyl alcohol to butyric acid, 0.5% catalyst （molar percent of butyric acid, the following as it）, 1.5-2.0 h, 5 mL cycloher, ane that act as water-carrying agent and at reflux temperature; the yield can reach 97.8%. Compared with some other Lewis acids, such as CuSO4·5 H2O, copper methanesulfonate has merits of easy seperation, and it was.used repeatedly 8 times without obvious loss of activity. Furthermore, the acid conversation still kept above 93.0%.