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碱性成纤维细胞生长因子在胃肠道间质瘤中的表达及临床意义

Expression and Clinical Significance of b-FGF in Gastrointestinal Stromal Tumors
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摘要 目的:研究碱性成纤维细胞生长因子(basic fibroblast growth factor,b-FGF)在胃肠道间质瘤(gastroin-testinal stromal tumors,GIST)中的表达及临床意义。方法:采用免疫组织化学法检测50例GIST中b-FGF的表达情况。结果:GIST中b-FGF表达阳性的组织微血管密度(microvessel density,MVD)显著高于表达阴性的MVD(P<0.05);b-FGF表达阳性者肿瘤直径显著大于b-FGF表达阴性者(P<0.05);b-FGF的表达与GIST的发生部位、核分裂多少、恶性潜力呈显著相关(均P<0.05)。结论:b-FGF是GIST的生物学行为和预后的重要标记物,阳性表达者恶性程度高,预后不良。 Objective:To explore the expression and clinical significances of basic fibroblast growth factor(b-FGF) in gastrointestinal stromal tumors (GIST). Methods: Samples of 50 cases with GIST were examined by immunohistochemical staining S-P method for the expression of b-FGF. Results: The density of microvessel density ( MVD ) in positive b- FGF cases was significantly higher than that in negative b-FGF cases (P 〈 0.05 ). The diameter of tumors in positive b- FGF cases was obviously bigger than that in negative b-FGF cases (P 〈 0.05). The expression of b-FGF significantly correlated with the site of tumor growing ( P 〈 0.05 ), the amount of karyoclasis ( P 〈 0.05 ) and the malignant potential of GIST ( P 〈 0. 05 ). Conclusions : b-FGF is an important marker reflecting the biological behaviors and prognosis of gastrointestinal stromal tumors. The positive expression of b-FGF suggests higher maligance and poor prognosis.
机构地区 山西省人民医院
出处 《山西职工医学院学报》 CAS 2012年第1期11-13,共3页 Journal of Shanxi Medical College for Continuing Education
关键词 胃肠道间质瘤 碱性成纤维细胞生长因子 微血管密度 免疫组织化学 gastrointestinal stromal tumors basic fibroblast growth factor microvessel density immunohistochemistry
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参考文献8

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