比较两种服药方法治疗小儿轮状病毒肠炎的疗效

Effect Comparison of Two Medication Regimens in Treating Children with Rotavirus Enteritis

目的:比较两种不同的服药方法服用枯草杆菌二联活菌颗粒(妈咪爱)和蒙脱石散(思密达)治疗小儿轮状病毒(RV)肠炎的疗效。方法:将86例RV肠炎患儿分为两组,观察组46例,先口服枯草杆菌二联活菌颗粒,1 h后再口服蒙脱石散,服蒙脱石散2 h后再进食(简称"1 h+2 h时间间隔法"),两药剂量是常规剂量的2倍(简称"剂量加倍法");对照组40例,随意时间服用枯草杆菌二联活菌颗粒和蒙脱石散,且均用常规剂量(简称"常规法")。两组患儿服用枯草杆菌二联活菌颗粒、蒙脱石散的次数相同。观察治疗后两组患儿大便次数、性状和症状的变化。结果:观察组大便次数恢复正常时间(4.63±1.53)d、大便性状恢复正常时间(4.59±1.14)d、退热时间(9.11±2.49)h、止吐时间(2.57±0.81)d,与对照组比较差异均有统计学意义(P<0.01或P<0.05)。72 h总有效率观察组95.7%,对照组67.5%,两组比较差异有统计学意义(χ2=9.902,P<0.01)。结论:采用"1 h+2 h时间间隔法"和"剂量加倍法"科学地服用枯草杆菌二联活菌颗粒和蒙脱石散治疗小儿RV肠炎,能迅速缓解临床症状,较快减少腹泻次数、改善大便性状和缩短腹泻病程。

Objective: To compare the effect of two drugs [Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines(Medilac-Vita) and montmorillonite powder(Smecta)] in the treatment of rotavirus enteritis in children through different regimens.Methods: Randomly 86 patients with rotavirus enteritis were divided into two groups: observation group and control group,46 patients in observation group took Medilac-Vita orally first,then took montmorillonite powder orally one hour later,finally took food after 2 hours(called '1 h+2 h time-interval method' for short),the dose of Medilac-Vita and montmorillonite powder were double of the common dose(called 'dose reduplication method' for short);40 patients in control group took Medilac-Vita and montmorillonite powder freely and used common dose(called 'routine method' for short).The medication frequency of the Medilac-Vita and montmorillonite powder in the two groups was the same.After the treatment,the changes of the defecation frequency,fecal characteristics and physical symptoms of the children in two groups were observed.Results: Compared to the control group,the recovery time of the stool frequency(4.63±1.53) d and fecal characteristics(4.59±1.14) d,the time of pyretolysis(9.11±2.49) h and stopping emesis(2.57±0.81) d in the observation group changed significantly.The differences were significant in statistics(P<0.01 or P<0.05).The total effective rates in 72 hours was 95.7% in the observation group and 67.5% in the control group,the difference was statistically significant(χ2=9.902,P<0.01).Conclusions: Curing rotavirus enteritis by taking Medilac-Vita and montmorillonite powder orally through the '1 h+2 h time-interval method' and 'dose reduplication method' could relieve clinical symptom quickly,reduce the defecation frequency,change the fecal characteristics and shorten the course of diarrhea.