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利妥昔单抗在难治性肾病综合征的应用进展 被引量：5

Application of Rituximab in Refractory Nephritic Syndrome
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摘要 利妥昔单抗（rituximab，RTX），商品名美罗华，是一种人鼠嵌合单克隆抗体，含1328个氨基酸，相对分子质量约144000。
作者 金雪锋 王墨
机构地区 重庆医科大学附属儿童医院
出处 《儿科药学杂志》 CAS 2012年第3期59-61,共3页 Journal of Pediatric Pharmacy
关键词 利妥昔单抗 难治性肾病综合征 抗CD20单克隆抗体 嵌合单克隆抗体 应用 相对分子质量 美罗华 商品名
分类号 R692.3 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

  • 1Edwards JC,Szczepanski L,Szechinski J,et al.Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoidarthritis[J].N Engl J Med,2004,350(25):2572-2581.
  • 2Marks SD,Patey S,Brogan PA,et al.B lymphocyte depletiontherapy in children with refractory systemic lupus erythematosus[J].Arthritis Rheum,2005,52(10):3168-3174.
  • 3Penalver FJ,Jimenez-Yuste V,Almagro M,et al.Rituximab inthe management of chronic immune thrombocytopenic purpura:aneffective and safe therapeutic alternative in refractory patients[J].Ann Hematol,2006,85(6):400-406.
  • 4Kurosu N,Sugiura H,Iwasaki C,et al.Successful Use of Single-Dose Rituximab for the Maintenance of Remission in a Patient withSteroid-Resistant Nephrotic Syndrome[J].Intern Med,2009,48(21):1901-1904.
  • 5Fujinaga S,Hirano D,Nishizaki N,et al.Single infusion ofrituximab for persistent steroid-dependent minimal-changenephrotic syndrome after long-term cyclosporine[J].PediatrNephrol,2010,25(3):539-544.
  • 6Kamei K,Ito S,Nozu K,et al.Single dose of rituximab forrefractory steroid-dependent nephrotic syndrome in children[J].Pediatr Nephrol,2009,24(7):1321-1328.
  • 7Prytula A,Iijima K,Kamei K,et al.Rituximab in refractorynephrotic syndrome[J].Pediatr Nephrol,2010,25(3):461-468.
  • 8Sellier-Leclerc AL,Macher MA,Loirat C,et al.Rituximabefficiency in children with steroid-dependent nephrotic syndrome[J].Pediatr Nephrol,2010,25(6):1109-1115.
  • 9Guigonis V,Dallocchio A,Baudouin V,et al.Rituximabtreatment for severe steroid-or cyclosporine-dependent nephroticsyndrome:a multicentric series of 22 cases[J].Pediatr Nephrol,2008,23(8):1269-1279.
  • 10Gulati A,Sinha A,Jordan SC,et al.Efficacy and safety oftreatment with rituximab for difficult steroid-resistant and-dependent nephrotic syndrome:multicentric report[J].Clin JAM SOC Nephrol,2010,5(12):2207-2212.

二级参考文献25

  • 1Reff ME, Career K, Chambers KS, et al. Depletion of B cells in vivo by chimeric mouse human monoclonal antibody to CD20. Blood, 1994,83:435-445.
  • 2Maloney DG, Smith B, Rose A. Rituximab : mechanism of action and resistance. Semin 0nco|,2002,29:2-9.
  • 3Glennie M J, French RR, Craqq MS, et al. Mechanisms of killing by anti-CD20 monoclonal antibodies . Mol Immunol,2007, 44 : 3823 -3837.
  • 4Lossis SN, Sfikakis PP. Sfikakis. Rituximab-induced B cell depletion in autoimmune diseases: Potential effects on T cells. Clin Immunol, 2008,127:280-285.
  • 5Kerjaschki D, Farquhar MG. lmmunocytochemical localization of the Heymann nephritis antigen (Gp330) in glomerular epithelial cells of normal Lewis rats. J Exp Med,1983, 157: 667-686.
  • 6Kemper MJ, Meyer-Jark T, Lilova M, et al. Combined T- and B- cell activation in childhood steroid sensitive nephrotic syndrome. Clin Nephrol,2003 ,60 :242-247.
  • 7Lagrue G, Branellec A, Blanc C, et al. A vascular permeability factor in lymphocyte culture supernants from patients with nephritic syndrome. II. Pharmacological and physicochemical properties. Biomedicine, 1975,23:73-75.
  • 8Cohen CD, Calvaresi N, ArmeUoni S, et al. CD20-positive infiltrates in human membranous glomerulonephritis. J Nephrol, 2005,18 : 328-333.
  • 9Remuzzi G, Chiurchiu C, Ruggenenti P, et al. Rituximab for idiopathic membranous nephropathy. Lancet,2002,360:923-924.
  • 10Smith GC. Is there a role for rituximab in the treatment of idiopathic childhood nephrotic syndrome.'? Pediatr Nephro, 2007, 122:893-898.

共引文献5

同被引文献28

引证文献5

二级引证文献14

儿科药学杂志
2012年 第3期

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