期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

粒细胞-巨噬细胞集落刺激因子在COPD中的研究进展 被引量：4

下载PDF
导出
摘要 粒细胞-巨噬细胞集落刺激因子(GM-CSF)可促进粒细胞、巨噬细胞的增殖、分化及功能成熟。而慢性阻塞性肺疾病(COPD)是一种以气道不完全可逆性阻塞为特征的慢性炎症性疾病。在COPD患者的气道、肺实质和肺血管中均存在着慢性炎症,中性粒细胞、巨噬细胞等均参与了COPD的慢性炎症过程。通过研究粒细胞-巨噬细胞集落刺激因子(GM-CSF)与气道炎症细胞的关系,以及气道炎症细胞在COPD中的作用机制,可以进一步探讨粒细胞-巨噬细胞集落刺激因子(GM-CSF)与COPD的形成与发展的关系。本文结合文献报道作一综述。
作者 王媛媛 李国平
机构地区 泸州医学院附属医院呼吸内科
出处 《西南军医》 2012年第1期140-142,共3页 Journal of Military Surgeon in Southwest China
关键词 粒细胞-巨噬细胞集落刺激因子 慢性阻塞性肺疾病 气道炎症细胞
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献27

  • 1Snider GL,Nosology for our day:it’s application to chronic obstruc-tive pulmonary disease[J].Am J Respir Crit Care Med,2003,167:178-683.
  • 2Rondini G,Chirico G.Hematopoietic growth factor levels in term andpreterm infants[J].Curr Opin Hematol,1999,6:192-197.
  • 3Sreenan C,Osiovich H.Myeloid colony-stimulating factors:use inthe newborn[J].Arch Pediatr Adolesc Med,1999,153:984-988.
  • 4Bracho F,Coldman S,Cairo MS,et al.Potential use of granulocytecolon-stimulating factor and granulocyte-macrophage colony-stim-ulating factor in neonates[J].Curr Opin Hematol,1998,5:215-220.
  • 5Hartung T.Anti-inflammatory effects of granulpocyte colony-stimu-lating factor[J].Curr Opin Hematol,1998,5:221-225.
  • 6S Saha,C Doe,V Mistry,et al.bronchial mucosa in asthma andCOPD factor expression in induced sputum and Granulocyte-macro-phage colony-stimulating Thorax,2009 64:671-676.
  • 7Fossati G,Mazzucchelli I,Gritti D,et al.In vitro effects of GM-CSF on mature peripheral blood neutrophils[J].Int J Mol Med 1998;1:943–951.
  • 8Baldwin GC.The biology of granulocyte-macrophage colony-stimu-lating factor:effects on hematopoietic and nonhematopoietic cells[J].Dev Biol 1992;151:352–367.
  • 9Yong KL,Linch DC.Differential effects of granulocyte-and granu-locyte-macrophage colony-stimulating factors(G-andGM-CSF)on neutrophil adhesion in vitro and in vivo[J].Eur J Haematol1992;49:251–259.
  • 10Weisbart RH,Golde DW,Clark SC,Wong GG,Gasson JC.Humangranulocyte-macrophage colony-stimulating factor is a neutrophilactivator[J].Nature 1985;314:361–363.

二级参考文献30

  • 1Snider GL. Nosology for our day:it's application to chronic obstructive pulmonary disease. Am J Respir Crit Care Med,2003 ,167 :178 ～ 683.
  • 2Finlay GA,ODriscoll LR, Russell KJ,et al. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am J Respir Crit Care Med, 1997,156:240 ～ 247.
  • 3Muley T, Wiebel M,Schulz V,et al. Elastinlytic activity of alveolar macrophages in smoking - associated pulmonary emphysem. Clin Invest,1994,72:269 ～ 276.
  • 4Eidelman DH,G hezzoh,Kin WD,et al. The destruction index and early lung destruction in smokers. An Rev Respir Dis,1991,144:156 ～ 159.
  • 5Ofulue AF, KOM. Effects of depletion of neutrophils of macrophages on development of cigarrete smoke - induced emphysema. Am J Physion,1999,27 :L97 ～ L105.
  • 6Sinder GL. Emphysema:the first two centries;Parts Ⅱ . Am Rev Respir Dis, 1992,146:1615 - 1622.
  • 7Saetta M, Di Stefano A,Turato G, et al. CD8 + T - lamphocytes in the peripheral airways of smokers with chronic pulmonary disease. Am J Respir Crit Care Med, 1998,157: 822 ～ 826.
  • 8Juanita H J. Vernooy, Mieke A, Dentener,et al. Long - term Intratracheal lipopolysaccharide exposure in mice result in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol,2002,26:152～159.
  • 9Majo J Chezzo H,Cosio MG Lymphocyte population and apoptosis in the lungs of smokders and their relation with the emphysema. Eur Respir J,2001,17:946 ～ 953.
  • 10Huninghake GW,Crystal RG Cigarette smoking and lung destruction:accumulation of neutrophils in the lung of cigarette smokers. Am Rev Respir Dis, 1983,128:833 ～ 838.

共引文献11

同被引文献41

引证文献4

二级引证文献63

西南军医
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部