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高糖环境下脂联素对人心肌细胞增殖的影响 被引量：1

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摘要 目的体外高糖培养人心肌细胞(HCM)及运用脂联素(ADPN)干预以探讨HCM增殖的影响,以揭示脂联素对高糖环境中的心肌细胞的可能保护作用。方法将HCM分为正常对照组(5.5mmol/L葡萄糖)、高糖组(30.0mmol/L葡萄糖)、脂联素组(30.0mmol/L+2.5μg/mlADPN),分别培养24h、48h、72h,运用MTT测定HCM的增殖情况。结果①在24h高糖组与正常组比较人心肌细胞增殖有促进作用(P<0.05),而高糖组与脂联素组比较没有统计学差异(P>0.05)。48、72h高糖组与正常对照组比较细胞增殖受抑制(P<0.05)。在加入脂联素后48、72h脂联素组与高糖组比较细胞增殖增加,随时间的延长细胞增殖增加明显,有统计学差异(P<0.05)。结论脂联素可以促进HCM增殖,对高糖环境下心肌细胞有保护作用。
作者 张俊洁 李兴
机构地区 山西医科大学第二医院内分泌科
出处 《中国现代药物应用》 2012年第4期45-46,共2页 Chinese Journal of Modern Drug Application
关键词 脂联素 人心肌细胞 糖尿病心肌病
分类号 R587.2 [医药卫生—内分泌]
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参考文献7

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中国现代药物应用
2012年 第4期

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