不同剂量阿托伐他汀对急性脑梗死患者高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α的影响

Influences of different doses of Atorvastatin on the serum levels of hs-CRP、IL-6 and TNF-α in acute cerebral infarction patients

目的探讨不同剂量阿托伐他汀对急性脑梗死患者高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)及肿瘤坏死因子α(TNF-α)水平的影响。方法选择84例急性脑梗死患者分为两组(A组和B组),在常规治疗的基础上,A组口服阿托伐他汀10 mg/d,B组采用口服阿托伐他汀20 mg/d,两组均治疗4周,观察两组患者用药前后hs-CRP、IL-6及TNF-α的变化。结果阿托伐他汀可降低急性脑梗死患者血清hs-CRP、IL-6及TNF-a水平,并呈量效关系。结论大剂量应用阿托伐他汀可明显减轻急性脑梗死炎性反应。

Objective To explore the influences of different doses of Atorvastatin on the serum levels of hs-CRP,IL-6 and TNF-α in acute cerebral infarction patients （ACI）. Methods 84 patients with ACI were recruited and randomly divided into two groups（group A and group B）. On the basic of conventional treatment, patients of group A took atorvastatin orally, 10 mg/d, while patients of group B took 20 mg/d,both for four weeks. The serum Levels of hs-CRP,IL-6 and TNF-α were detected before and after 4 weeks of treatment. Results The serum Levels of hs-CRP, IL-6 atorvastatin, and a dose-response relationship were shown. Conclusions inflammatory response in ACI patients. and TNF-c~ decreased after four weeks of treatment with Usage of high-dose atorvastatin may significantly reduce the inflammatory response in ACI patients.