COPD营养状况与炎症反应的关系研究

The relationship between nutrition and inflammation in COPD patients

目的了解慢性阻塞性肺疾病患者营养状况与炎症反应的关系,探讨COPD营养不良的发生机制。方法选取我院COPD数据库中的稳定期COPD患者84例,测定其各项营养指标及血清及诱导痰的各项炎症因子,了解营养指标与炎症因子的相关性。结果 COPD营养不良者血清及诱导痰各项炎症指标高于营养正常组。COPD患者血清各项炎症指标包括IL-1、IL-8、TNF-α,与体重指数、理想体重百分比以及血清白蛋白呈负相关。而与三头肌皮褶厚度、上臂围相关性无统计学意义。结论 COPD营养不良的发生与全身炎症反应密切相关。

Objective To study the relationship between nutrition and inflammation, investigate the mechanism of malnutrition in COPD patients. Methods All patients were choosed from our COPD database, the nutritional status and inflammation factors were measured to understand the correlation between malnutrition and inflammation. Results All inflammation factors are significant higher in malnutrition patients than normotrophic patients, all inflammation factors including IL-1, IL-8 and TNF-αare negative correlative with BMI,IBW and ALB ,but there are no statistical significance between inflam- mation factors and TSF or MAC. Conclusion There are close relationship between malnutrition and Systemic inflammatory response.