摘要
目的检测结直肠癌术后组织中组织蛋白酶-D(Cath-D)和生存素(Survivin)的表达特点,探讨Cath-D和Sur-vivin的表达关系及对预后的判断价值。方法应用流式细胞术检测80例结直肠癌标本和50例正常结肠黏膜组织中Cath-D和Survivin的表达,分析Cath-D和Survivin在不同临床特征中的表达差别,关注其表达及对预后的判断意义。结果结肠癌中Cath-D和Survivin的表达量明显高于正常结肠黏膜组织,Cath-D和Survivin的表达与结直肠癌的浸润深度、Dukes分期及淋巴结转移有关,结直肠癌中Cath-D和Survivin的表达具有正相关性,生存分析显示Cath-D和Survivin的表达与患者的预后有关。结论结直肠癌中Cath-D和Survivin高表达,Cath-D和Survivin蛋白可能具有协同作用,对肿瘤的进展具有一定的促进作用,联合检测Cath-D和Survivin的表达可能与患者的预后有关。
Objective To investigate the protein expressions on of Cath-D and Survivin, observe their relationship and clinical significance in colorectal carcinoma. Methods We detected the protein expressions of Cath-D and Survivin by FCM in the colorectal carcinoma （80 cases） and normal colorectal tissues （50 cases）. Their expression relationship and differ- ent pathological characters were analyzed in the colorectal carcinoma. Results The, protein expressions of Cath-D and Survivin were higher in the neoplasm than in normal colorectal tissues. Their expressions were correlated with invasive depth, Dukes stages and lymph node metastasis. Positive correlation between cath-D and survivin protein were found in neoplasm. Their expressions of Cath-D and Survivin were correlated with prognosis. Conclusion The higher expressions of Cath-D and Survivin were found in colorectal carcinoma. The combined detection of Cath-D and Survivin may be help to judge progno- sis of neoplasm.
出处
《中国现代医生》
2012年第8期77-78,共2页
China Modern Doctor
