孟鲁司特治疗婴儿哮喘24例临床观察

Infant asthema treated with montelukast:A clinical observation of 24 cases

目的观察孟鲁司特治疗0.5～1岁内婴儿哮喘的疗效。方法将24例轻-中度发作期的哮喘婴儿随机分为观察组及对照组各12例。观察组给予布地耐德悬液1mL(0.5 mg)雾化吸入,同时孟鲁司特每晚4 mg,对照组予布地耐德悬液1mL(0.5 mg),疗程3周。急性发作时均加强抗感染,雾化液中加入β2受体激动剂特布他林,观察比较两组的疗效。结果观察3周,治疗组的多项哮喘控制指标得到明显改善,与对照组比较有统计学意义(P<0.05)。结论糖皮质激素吸入治疗婴儿哮喘有效,联合孟鲁司特治疗可缩短病程。

Objective To observe the curative effect of montelukast for 24 cases of infants with asthema whose ages from 0.5 to 1 year old. Methods Divided 24 cases of infants with mild-moderate onseting stage asthema into observating group and control group,12 cases for each group. Aerosol inhalation with budesonide suspension lml （0.Smg） for observation group,combined with 4mg of montelukast orally every night, and Aerosol inhalation with budesonide suspension lml（0.Smg） for control group only, a course of treatment for 3 weeks respectively. Antimicrobial agents was administered when asthema onset in acute stage, combined with inhalation of terbutaline for ^-receptor angonist, make observation to treating effect of two groups comparatively. Results After 3 weeks, muhiterm of asthema controlling index for treatment group abtained im- provement obviously, showing significant difference（P 〈0. 05 ）compared with control group. Conclusion Treatment to infant asthema with glucocorticoid be effective measures ,combined with taking Montelukast orally every night reduce treatment cou^ce