Galectin-3蛋白在结直肠癌中的表达及临床意义

Expression of Galectin-3 protein in colorectal cancer and their clinical effects

目的研究Galectin-3蛋白在结直肠癌中的表达及其与临床病理特征的关系。方法采用快捷免疫组化MaxVi-sionTM法对50例正常结肠黏膜组织、60例结肠腺瘤性息肉组织、152例结直肠癌中Galectin-3蛋白进行检测。结果 Galec-tin-3蛋白在结直肠癌中的阳性率与正常结肠黏膜组织、结肠腺瘤性息肉组织相比,其差异均有统计学意义(P<0.05)。在结直肠癌中,Galectin-3蛋白的表达与肿瘤的临床分期、组织的分化程度及有无淋巴结转移有关,临床分期越晚、组织分化越差,Galectin-3蛋白表达越高,有淋巴结转移组的表达率高于无淋巴结转移组,其差异均有统计学意义(P<0.05)。结论 Galec-tin-3蛋白在结直肠癌的发生发展中起着重要作用。

Objective To investigate the expression of Galectin-3 protein in colorectal cancer and to find out their relationships with clinical pathological features.Methods Expression of Galectin-3 protein was detected in 50 cases of normal mucosa tissues,60 cases of adenoma tissues and 152 cases of colorectal cancer tissues with immunohistochemical MaxVisionTM technique.Results There was significant difference（P〈0.05） for the positive rates of Galectin-3 protein in colorectal cancer in tissues,normal mucosa tissues and adenoma tissues.In colorectal cancer tissues,expression of Galectin-3 Protein was closely related to clinical stage,differentiated degree and lymph node metastasis.With clinical stage later and differentiated degree worse,expression of Galectin-3 Protein became more higher.Expression of Galectin-3 protein was higher in lymph node metastasis than that without lymph node metastasis,there was significant difference（P〈0.05）.Conclusion Galectin-3 protein plays an important role in the oncogenesis and development of colorectal cancer.