12例胃肠道间质瘤合并消化道癌临床病理分析

目的:探讨12例胃肠道间质瘤(GIST)合并消化道癌的临床病理特征。方法:回顾性研究116例GIST,用光镜观察其中12例合并发生消化道癌的病理特征及免疫组化的表达情况。结果:GIST合并发生消化道癌的病例占所有收集GIST病例的10.34%,免疫表型CD117阳性表达10例、DOG1阳性表达11例、CD34阳性表达8例、SMA阳性表达6例,肿瘤TNM分期0期1例,Ⅰ期2例,Ⅱ期5例,Ⅲ期4例。结论:本病好发于老年男性,其中GIST多发生于胃且生物学危险度低,合并的消化道癌多为胃癌和食管癌,DOG1能帮助鉴别诊断其他胃肠道间叶源性肿瘤。

Objective：To investigate 12 cases of gastrointestinal stromal tumor（GIST） with digestive tract carcinoma.Methods：a retrospective study of 116 cases of GIST,with light microscopic observation of 12 cases with digestive tract cancer ：pathology and immunohistochemical expression.Results：GIST complicated with digestive tract cancer cases accounted for the collection of all cases of GIST 10.34%,the positive expression of CD117 immune phenotype in 10 cases,the positive expression of DOG1 in 11 cases,the positive expression of CD34 in 8 cases,the positive expression of SMA in 6 cases,tumor TNM stage 0 stage 1 cases,phase I in 2 patients,including 5 cases of stage II,III in 4 cases.Conclusion：the disease occurs in older men,where GIST occurs in the stomach and biological risk degree is low,and the cancer of digestive tract for gastric and esophageal cancer,DOG1 can help in the differential diagnosis of other gastrointestinal mesenchymal tumors.