盐酸贝那普利联合泼尼松治疗小儿原发性肾病综合征

The clinical therapeutic effect of benazepril hydrochloride combined with prednisone on children’s primary nephritic syndrome

目的观察盐酸贝那普利联合泼尼松治疗原发性肾病综合征的疗效和安全性。方法 40例患者随机分为两组:治疗组20例服用盐酸贝那普利0.1～0.3mg/kg.d,泼尼松片2mg/kg.d;对照组20例服用泼尼松片2mg/kg.d。疗程8周。观察24h尿蛋白定量、血清肌肝、血清白蛋白及血钾等变化及不良反应情况。结果治疗4周后两组24h尿蛋白定量、总有效率比较差异有统计学意义(P<0.05),治疗前及8周后两组24h尿蛋白定量、总有效率比较差异无统计学意义(P>0.05)。两组在治疗过程中,血清肌肝及血钾差异无统计学意义(P>0.05)。结论盐酸贝那普利联合泼尼松治疗原发性肾病综合征安全,早期有效,其疗效优于泼尼松。

Objective To observe the therapeutic effect and safety of benazepril hydrochloride combined with prednisone on patients with primary nephritic syndrome.Methods Forty patients were divided into two groups at random.Patients took benazepril hydrochloride 0.1～0.3mg/kg.d plus prednisone 2mg/kg.d in treated group（20 cases） ,and prednisone 2mg/kg.d in control group（20 cases） for eight weeks.Urine protein,serum creatine,serum albumin,serum potassium and adverse effects were detected during the trial.Results After four weeks of therapy,24-hour proteinuria and total effective rate had statistically significant（P0.05） ,and there were no statistical difference after eight weeks and pretherapy between treated group and control group（P0.05） .There were no statistical difference in serum creatine and serum potassium between treated group and control group（P0.05） .Conclusion It is safe to treat primary nephritic syndrome with benazepril hydrochloride combined with prednisone,and effective in earlier period.It is superior to prednisone.