期刊文献+

吸入布地奈德福莫特罗对支气管哮喘患者诱导痰嗜酸细胞趋化因子及IL-17的影响

下载PDF
导出
摘要 目的探讨支气管哮喘患者在吸入布地奈德福莫特罗干粉吸入剂治疗前后,其诱导痰中嗜酸细胞趋化因子(Eotaxin)及IL-17含量发生变化的临床意义。方法采用酶联免疫吸附法检测36例支气管哮喘患者(包括28例缓解期气管哮喘患者)吸入布地奈德福莫特罗干粉进行治疗前后诱导痰中嗜酸细胞趋化因子及IL-17产生的变化,并与30例健康对照组受试者的相关情况进行比较。结果支气管哮喘患者在病情急性发作期间布地奈德福莫特罗干粉后,诱导痰内嗜酸细胞趋化因子的含量明显高于缓解期的此病患者和健康对照组的受试者(P<0.05),急性发作期此病患者诱导痰中IL-17的含量明显高于健康对照组受试者(P<0.001)。结论吸入布地奈德福莫特罗可显著降低支气管哮喘患者病情急性发作期间体内嗜酸细胞趋化因子的含量,可减少气道分泌物中嗜酸粒细胞的含量。IL-17参与了支气管哮喘的气道炎症反应过程。
作者 郭安奎
出处 《求医问药(下半月刊)》 2011年第11期721-722,共2页 Seek Medical and Ask The Medicine
  • 相关文献

参考文献7

  • 1沈锋,赵鸣武,贺蓓,王玉柱,姚婉贞.慢性阻塞性肺疾病和支气管哮喘患者诱导痰中白细胞介素-17水平及其意义[J].中华内科杂志,2004,43(12):888-890. 被引量:27
  • 2支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗、疗效判断标准及教育和管理方案)[J]中华结核和呼吸杂志,1997(05).
  • 3Im GJ,,Hwang CS,Jung HH.Quantitative expression levels of regulated on activation,normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate allergic rats. Acta Oto laryngologica . 2005
  • 4Miyamoto M,Prause O,Sjostrand M, et al.Endogenous IL-17 as a mediator of neut rophil recruitment caused by endotoxin exposure in mouse airways. J Immunol . 2003
  • 5Oboki K,Ohno T,Saito H,Nakae S.Th17and allergy. Allergology International . 2008
  • 6R. A. Taha,S. Laberge,Q. Hamid,R. Olivenstein.Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Chest . 2001
  • 7Pin I,Gibson PG,Kolendowicz R,et al.Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax . 1992

二级参考文献5

  • 1Yao Z, Painter SL, Fanslow WC, et al.Human IL-17: a novel cytokine derived from T cells.J Immunol,1995,155:5483-5486.
  • 2Laan M, Cui ZH, Hoshino H,et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.J Immunol,1999,162:2347-2352.
  • 3Molet S, Hamid Q, Davoine F,et al.IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.J Allergy Clin Immunol,2001,108:430-438.
  • 4Larsson R, Rocksen D, Lilliehook B, et al.Dose-dependent activation of lymphocytes in endotoxin-induced airway inflammation.Infect Immun,2000,68:6962-6969.
  • 5Striz I, Mio T, Adachi Y, et al.Th2-type cytokines modulate IL-6 release by human bronchial epithelial cells.Immunol Lett,1999,70:83-88.

共引文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部