摘要
目的:观察血管紧张素转换酶抑制剂(ACEI)和血管紧张素受体拮抗剂(ARB)对慢性肾脏病(CKD)所致蛋白尿的治疗作用。方法:将46例患者随机分成三组,分别接受ACEI、ARB、ACEI+ARB治疗三个月,观察治疗前后患者的血压、24小时尿蛋白定量、血肌酐、血尿素氮、血尿酸、血钾的变化。结果:通过治疗后,三组患者的血压及24小时尿蛋白定量均比治疗前下降,结果具有统计学意义,其他各项检查在治疗前后差异无统计学意义。结论:ACEI和ARB均有减少CKD患者蛋白尿的作用,而且两者联合疗效更佳。
Objective To observe the therapeutic effect of angiotensin converting enzyme inhibitors（ACEI） and angiotensin receptor blocker（ARB） on the proteinuria caused by Chronic kidney disease（CKD）.Methods Selected 46 patients were randomly divided into three groups and received therapy with ACEI,ARB and ACEI＋ARB for three months,respectively.To observe the change of blood pressure,24-hour urinary protein count,creatinine（Cr）,blood urea nitrogen（BUN）,uric acid（UA） and blood potassium before and after treatment.Results Both blood pressure and 24-hour urinary protein count of three groups decreased after treatment,which is statistically significant.All the other examining treatments had no statistically significant difference before and after treatments.Conclusion ACEI and ARB take the role of reducing the proteinuria of the patient and the effect of combined therapy is better.
出处
《求医问药（下半月刊）》
2011年第12期5-5,共1页
Seek Medical and Ask The Medicine
