乙胺碘呋酮对甲状腺功能的影响——附32例分析

THE EFFECTS OF AMIODARONE ON THYROID FUNCTION——Analysis of S2 Cases

本文对32例应用乙胺碘呋酮治疗心律失常的病人进行了系统观察药物对甲状腺功能的影响,发现有11例(34.4％)发生甲亢或甲亢复发,2例(6.3％)发生甲状腺功能低减。另有10例(31.2％)呈无症状的高T_4血症。甲状腺功能总改变率为71.9％。

Amiodarone, an efficacious antiarrythmic drug has effect on thyroid function. These effects haveban investigated in our hospital in the period Jan. 1930——May 19S6. 32 patients with cardiac arry-thmia were treated in different periods of time from 2 days to 3 years and with various total dosages from 1.2 to 199gm. 23 cases (71.9%) had various thyroid dysfunctions. Among them, 11 (34.4%) developed hyperthyroidism, 2 (6.3%) developed hypothyroidism and 10 casses (31.3%) had obvious elevation in serum thyroxine concentration, though symptomless. we found that all of the 5 cases having a history of thyrotoxicosis had an abnormality of thyroid functions, after taking amiodarone, whereas, 18(63.7%) dysfunction of 27 patients with normal thyroid before the therapy devaloped thyroid. we have also found that there is a concurriat effect of amiodarone and uracil on the treatment of arrylhaiia in hyperthyroidism.