不同剂量舒利迭吸入剂对轻中度COPD患者的疗效观察

Study of effectiveness of using inhalation different dosages in the treatment of Mild and Moderate COPD patients

目的观察不同剂量舒利迭治疗轻中度COPD稳定期的疗效。方法我院就诊的轻中度COPD稳定期患者134例,随机分为A、B、C三组。A组(对照组)给予常规治疗,B组在常规治疗基础上再加吸入舒利迭50 ug/250 ug,C组在常规治疗基础上再加吸入舒利迭50 ug/500 ug,分别评估各组治疗期、治疗6个月及治疗1年后的肺功能指标、临床症状评分,治疗后急性加重次数及药物不良反应。结果舒利迭治疗后总有效率优于常规治疗组(P<0.05),大剂量疗效略优于小剂量,但两者无统计学意义(P>0.05)。结论舒利迭吸入治疗轻中度COPD稳定期能改善患者的临床症状及肺功能。

Objective To observe the efficacy of seretide with different dosages in treatment of chronic obstructive pulmonary disease（COPD）.Methods In the treatment of mild and moderate 134 patients with COPD,the patients were randomly divided into group A（control group）,group B（given 50 μg/250 μg） and group C（given 50 μg/500 μg）.The control group was given conventional treatment.Each group＇s lung function,the clinical symptoms and the number of outbreaks of acute COPD were analyzed and compared at 6 months and 1 year after the treatment.Results The total effective rate of group B and C was higher than that of group A（P0.05）,the effects of high dose seretide is better than that of low dose.but they were no significant differences（P0.05）.Conclusion Seretide in the treatment of mild and moderate COPD during the mitigation has obvious improvement of their clinical symptoms and the lung function.