磷霉素致不良反应175例文献分析

Literature Analysis of Fosfomycin-induced of 175 Cases ADR

目的:探讨磷霉素致不良反应(ADR)发生的特点,为临床安全用药提供参考。方法:检索中国期刊全文数据库(CNKI)收载的1996-2010年国内医药学期刊有关磷霉素致ADR文献113篇,并按患者姓别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果:收集磷霉素致ADR175例,全身性损害最多,为73例(41.71%),其中过敏性休克54例(30.86%),其次为皮肤及附件损害49例(28.00%),神经系统损害20例(14.43%);ADR最短的在用药1min内发生,最长的在用药8d后发生;61例属于新的严重的ADR。结论:临床应重视磷霉素致新的严重的ADR,加强用药监测,以减少ADR的重复发生。

OBJECTIVE： To study the characteristics of the ADR associated with fosfomycin to guide rational drug use. METH- ODS： Retrieved from domestic medical journals recorded by CNKI during 1996-2010, a total of 113 literatures about fosfomycin-inducing ADR were collected and analyzed statistically in respect of patients＇ gender and age, primary disease, allergic history, route of administration, organs or systems involved and clinical manifestation, ere, RESULTS： A total of 175 ADR cases were obtained. 73 cases suffered from systemic lesion （41.71% ）, among which there were 54 cases anaphylactic shock （30.86%）, followed by lesion of skin and its appendants （n=49, 28.00% ）, lesion of nervous system （n=20, 14.43% ）. The earliest ADR occurred within 1 min after administration while the latest occurred 8 d after administration. There were 61 cases of new serious ADR. CONCLUSION： More attention should be paid to new serious ADR induced by fosfomycin. ADR monitoring should be strength- ened to reduce the occurrence of ADR.