参麦注射液致过敏性休克23例文献分析

Literature Analysis of 23 Cases of Shenmai Injection-induced Anaphylactic Shock

目的:探讨参麦注射液致过敏性休克的规律和特点,为临床合理用药提供参考。方法:检索国内医药数据库,下载参麦注射液致过敏性休克病例报告全文,对资料进行统计与分析。结果:共检索到23篇参麦注射液致过敏性休克病例报道,合计23例病例。其中,30岁以上的女性多见(15例,占65.22%),均是静脉注射给药,20例发生在首次用药(86.96%),22例(95.65%)发生在静脉滴注开始后的20min以内,临床表现以胸闷、血压下降、呼吸困难、脸色苍白、出汗等为主。经积极的抗过敏性休克抢救,全部病例恢复正常,无死亡病例。用药前未详细询问患者用药史与药物过敏史,与其他中药注射剂同瓶静脉滴注、医务人员对患者用药初期出现的不良反应未予重视是发生过敏性休克的安全隐患。结论:参麦注射液致过敏性休克并不少见,临床医务工作者应重视。

OBJECTIVE： To investigate the rules and characteristics of Shenmai injection-induced anaphylactic shock, and to provide reference for rational use of national essential drugs in the clinic. METHODS： By retrieving relevant domestic pharmaceutical database, the reports of Shenmai injection-induced anaphylactic shock were downloaded, and the relevant data related to anaphylactic shock were analyzed statistically. RESULTS： A total of 23 literatures were retrieved, including 23 cases of Shenmai injection-induced anaphylactic shock. Most of patients were middle-aged and old women with 30 years of age above （15 cases, account- ing for 65.22% ）. All cases were caused by intravenous injection. Most of them occurred at the first medication （20 cases, accounting for 86.96% ）, and 95.65% （22 cases） appeared within 20 rain after intravenous infusion. Clinical manifestations of anaphylactic shock mainly were chest tightness, blood pressure decreasing, difficulty in breathing, pallor, sweating, etc. After active anti-anaphylactic shock rescue, all patients returned to normal, with no deaths. Medical staff didn＇ t ask patients medication history and drug allergy history in details before treatment and intravenous injection of Shenmain injection combined with other TCM injection in same bottle. Medical staff didn＇ t pay attention to ADR at the initial treatment stage. Above all were security risks to anaphylactic shock. CONCLUSIONS： Shenmai injection-induced anaphylactic shock is not a rare thing, and clinical medical workers should pay attention to serious ADR caused by Shenmai injection.