摘要
目的研究GNAS1基因T393C多态性与肾透明细胞癌的临床分期和病理分级的关系。方法收集42例手术切除肾透明细胞癌的标本,应用PCR-限制性片段长度多态性法,对肾透明细胞癌患者和健康查体者进行基因多态性的比较。结果在GNAS1基因T393C多态性与肾透明细胞癌的病理分级及临床分期无明显相关性(P>0.05)。结论 GNAS1基因T393C多态性与肾透明细胞癌的临床分期及病理分级无明显相关关系。
Objective To analyze the relationship between T393C polymorphism of GNAS1 and clinical stages and pathological grades of renal clear cell carcinoma（RCCC）.Methods The T393C polymorphisms of GNAS1 were determined by polymerase chain reaction with restriction fragment length polymorphism in 42 cases with RCCC.Results The GNAS1 T393C polymorphism was not significantly correlated with RCCC stages and grades（P0.05）.Conclusion The GNAS1 T393C polymorphism is not significantly associated with RCCC staging and grading.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第5期525-527,共3页
Jiangsu Medical Journal
