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EZH2和microRNA-101在急性髓系白血病中的相关性分析及对预后的影响 被引量：10

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摘要 EZH2基因（enhancer of zeste homolog 2，EZH2）是果蝇ZESTE基因增强子的人类同源物，是PcG（Polycomb Group）家族中PRC2复合物的重要成员之一。
作者 吴圣豪 郑翠苹 徐杰
机构地区 温州市第二人民医院
出处 《中华血液学杂志》 CAS CSCD 北大核心 2012年第3期232-235,共4页 Chinese Journal of Hematology
关键词 EZH2基因 急性髓系白血病 相关性分析 HOMOLOG 预后 增强子 E基因 复合物
分类号 R733.71 [医药卫生—肿瘤]
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参考文献14

  • 1Tonini T, Bagella L, D' Andrilli G, et al. Ezh2 reduces the ability of HDACl-dependent pRb2/pl30 transcriptional repression of cyc- lin A. Oneogene, 2004, 23:4930-4937.
  • 2Melnick AM. Epigeneties in AML. Best Pract Res Clin Haematol, 2010, 23:463-468.
  • 3Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature, 2002, 419:624-629.
  • 4Varambally S, Cao Q, Mani RS, et al Genomic loss of mieroR- NA-101 leads to overexpression of histone methyhransferase EZH2 in cancer. Science, 2008, 322 : 1695-1699.
  • 5Kirmizis A, Bartley SM, Kuzmichev A, et al. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev, 2004, 18 : 1592-1605.
  • 6Aoto T, Saitoh N, Sakamoto Y, et al. Polycomb group protein-as- sociated ehromatin is reproduced in post-mitotic G1 phase and is required for S phase progression. J Biol Chem, 2008, 283:18905- 18915.
  • 7Saramiki OR, Tammela TL, Martikainen PM, et al. The gene fi~r polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Genes Chromosomes Cam'.- er, 2006, 45:639-645.
  • 8Mimori K, Ogawa K, Okamoto M, et al. Clinical signil'icanee of enhancer of zeste homolog 2 expression in colorectal cancer cases. Eur J Surg Oncol, 2005, 31:376-380.
  • 9Collett K, Eide GE, Ames J, et al. Expression of enhancer of zes- te homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res, 2006, 12:1168-1174.
  • 10Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet, 2010, 42:722-726.

同被引文献90

  • 1乔淑凯,徐世荣,郭晓楠,王颖.急性白血病患者DNA甲基转移酶基因的表达其及临床意义[J].中国实验血液学杂志,2005,13(2):260-265. 被引量：6
  • 2Sauvageau M, Sauvageau G. Polycomb group proteins: multi- faceted regulators of somatic stem cells and cancer[J]. Cell stem cell, 2010, 7(3):299-313.
  • 3Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer [J]. Nature, 2002, 419(6907) :624-629.
  • 4Wan L, Li X, Shen H, et al. Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pat hological characteristics[J ]. Clin Transl Oncol, 2013, 15 (2) : 132-138.
  • 5Cao W, Ribeiro Rde O, Liu D, et al. EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer[J]. PloS One, 2012, 7(12) :e52984.
  • 6He LR, Liu MZ, Li BK, et al. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy[J]. |nt J Cancer, 2010, 127 (1) .. 138-147.
  • 7Wang H, Albadine R, Magheli A, et al. Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder[J]. Urol Oncol, 2012, 30 (4) .. 428- 433.
  • 8Zhang Y, Liu G, Lin C, et al. Silencing the EZH2 gene by RNA interference reverses the drug resistance of human hepatic multidrug-resistant cancer cells to 5-Fu[J]. Life Sci, 2013, 92 (17-19) : 896-902.
  • 9Mnrin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lympbomas of germinal-center origin [J]. Nat Genet, 2010, 42(2) ..181-185.
  • 10Sneeringer CJ, Scott MP, Kuntz KW, et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on bistone H3 (H3K27) in human B-cell lymphomas[J]. Proc Natl Acad Sci U S A, 2010, 107(49) ..20980-20985.

引证文献10

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中华血液学杂志
2012年 第3期

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