肝移植组织中调节性T淋巴细胞的表达及分布

Expression and distribution of regulatory T lymphocytes in liver transplant tissues

背景:调节性T细胞在动物肝脏移植免疫耐受诱导中起重要作用。目的:探讨调节性T细胞在肝移植组织中的表达与分布。方法:由第一作者检索Medline数据库1990-01/2010-12,万方医学网1990-01/2010-12,中国医院知识仓库1998-01/2010-12文献。英文检索词为"liver transplantation,rejection,immune tolerance,regulatory T cells";中文检索词为"肝移植,排斥反应,免疫耐受,调节性T淋巴细胞"。结果与结论:调节性T淋巴细胞是调节机体免疫应答的一类重要调节性细胞,具有辅助体液和细胞免疫的功能,调节性T淋巴细胞及其细胞因子在肝移植免疫中起十分重要的作用:Th1/rh2的平衡与肝移植后免疫反应密切相关,Th1细胞因子分泌增加可致肝移植排斥反应,当Th1/rh2向Th2偏移,易发生免疫耐受反应。临床评价肝移植患者免疫状态需要联合ImmuKnow、T淋巴细胞、血药浓度、肝功能指标检测等相关检查,来有效指导肝移植受体免疫抑制剂的个体化使用。

BACKGROUND：Regulatory T cells play an important role in the immune tolerance induction of liver transplantation in animals.OBJECTIVE：To explore the expression and distribution of regulatory T cells in the liver transplantation tissues.METHODS：An online search of Medline（1990-01/2010-12）,Wanfang Med Online（1990-01/2010-12） and China Hospital Knowledge Database（1998-01/2010-12） was performed for the related articles with the Key words of ＂liver transplantation,rejection immune tolerance,regulatory T cells＂ in English and in Chinese.RESULTS AND CONCLUSION：Regulatory T lymphocytes are one of the major regulatory cells in the regulation of the immune response;they assist the humoral and cell-mediated immunity.Regulatory T lymphocytes and their cytokines play a very import role in the immunoreactions of liver transplantation：the balance of Th1/rh2 is closely related with the immunoreactions after liver transplantation;the increased secretion of Th1 cytokine causes liver transplant rejection.Immune tolerance reactions are more likely to occur when the Th1/rh2 balance shifts to Th2.Clinical evaluation of the immune status in liver transplantation patients should be combined with ImmuKnow,T lymphocytes,plasma concentration,liver function testing and other related inspection,therefore the individual use of immunosuppressive agents in liver transplant recipients can be effectively guided.