血清铁蛋白水平与非酒精性脂肪肝及相关危险因素关系

Association of serum ferritin level with non-alcoholic fatty liver disease and its related risk factors

目的分析体检人群血清铁蛋白水平与非酒精性脂肪肝及其相关危险因素的关系。方法单纯非酒精性脂肪肝患者222例为观察组,体检健康者192例为对照组,检测2组血脂指标、体质量指数、血压、肝功能、空腹血糖、血尿酸等,并行肝脏B超检查,测定血清铁蛋白水平,分析其与上述指标的相关性。结果观察组体质量指数、收缩压、男性舒张压、空腹血糖、血尿酸、三酰甘油、总胆固醇、丙氨酸氨基转移酶、门冬氨酸氨基转移酶、谷氨酸转肽酶及铁蛋白水平均高于对照组(P<0.05),高密度脂蛋白胆固醇低于对照组(P<0.05);血清铁蛋白水平与谷氨酸转肽酶、舒张压、血尿酸、空腹血糖呈正相关(P<0.05)。结论血清铁蛋白水平增高是引起非酒精性脂肪肝危险因素之一。

Objective To explore the relationship of serum ferritin level with non-alcoholic fatty liver disease （NAFLD） and its related risk factors in physical examination subjects. Methods A total of 222 cases of NAFLD and 196 health controls received abdominal ultrasound examination and were detected the levels of body mass index, blood pressure, liver function, fasting plasma glucose, serum uric acid and serum ferritin. The relationship between the above indexes and serum ferritin was analaysed. Results The body mass index, systolic blood pressure, diastolic blood pressure in males, fasting plasma glucose, serum uric acid, triacylglycerol, total cholesterol, aspartate aminotransferase, alanine aminotransferase, Y-glutamyl transpeptidase and serum ferritin were significantly higher in NAFLD group than those in control group（P〈0.05）. The high density lipoprotein-cholesterol level was lower in NAFLD group than that in control group（P〈 0.05）. Correlation analysis showed y-glutamyl transpeptidase, diastolic blood pressure, serum uric acid, fasting plasma glucose were positively correlated with the levels of serum ferritin （P〈 0.05）. Conclusion Increased serum ferritin is one of the risk factors for NAFLD.