摘要
目的探讨尿胱抑素C(cystatin C,Cyst C)和尿转铁蛋白(transferrin,TRF)联合检测与尿β2-微球蛋白(β2-microglobulin,β2-MG)和尿微量白蛋白(microalbuminuria,mALB)联合检测诊断早期糖尿病肾病的临床价值。方法 238例2型糖尿病患者中mALB≤30mg/24h者118例为A组,mALB>30～220mg/24h者120例为B组;210例体检健康者为对照C组。采用ELISA法检测尿Cyst C,TRF,β2-MG,mALB,比较尿Cyst C和尿TRF联合检测与尿β2-MG和mALB联合检测对早期糖尿病肾病的诊断价值。结果经非参数检验分析,3组间差异均有统计学意义(P<0.01);尿Cyst C的AUC(0.645)<尿β2-MG AUC(0.794),尿TRF的AUC(0.783)>尿mALB的AUC(0.768);尿mALB和β2-MG二者联合检测阳性率60.9%高于尿CystC和TRF二者联合检测阳性率51.3%(P<0.01)。结论 2种联合检测方法对早期糖尿病肾病诊断均有价值。
Objective To explore the clinical value of the combination detection of urinary cystatin C and transferrin, and the combination detection of urinary 132-microglobulin（132 MG） and microalbuminuria （mALB） to the diagnosis of early diabetic nephropathy. Methods A total of 238 patients with type 2 diabetes mellitus were divided into 2 groups according to the level of 24-hour urinary albumin（UAlb）, 118 cases in group A （mAI.B〈30 rag/24 h）, and 120 cases in group B （mALB from 30 to 220 rag/24 h）. Another 210 healthy subjects were as controls （group C）. The levels of cystatin C, transferrin, 132-MG and mALB were respectively detected with ELISA technique to compare the diagnostic value of the detection of cystatin C and transferrin, and the detection of 132-MG and with mALB to the early diabetic nephropathy. Results The nonparametric analysis showed there was significant differences among the three groups（P〈 0.01）. AUC of the cystatin C（0. 645） was smaller than that of the 132-MG（0. 794）, and AUC of transfferrin （0. 783） was larger than that of mALB（0. 768）. The positive rate of cystatin C combined with transfferrin（60.9%） was significantly higher than that of 132-MG combined with mALB（51.3 % ）, which showed a significant difference（P〈0.01）. Conclusion Both of these two combination methods contribute to the diagnosis of early diabetic nephropathy.
出处
《中华实用诊断与治疗杂志》
2012年第3期249-251,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
新疆维吾尔自治区科技攻关项目(200910015)
