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胶质瘤功能连接网络的静息态脑磁图研究 被引量:1

Unctional connectivity network analysis of glioma by resting-state magnetoencephalography
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摘要 目的通过静息态脑磁图评估胶质瘤对人类大脑功能连接网络的影响。方法本研究共采集20例胶质瘤患者及20例健康受试者的静息态脑磁图数据,在Delta频段,Theta频段,Alpha频段,Beta频段,低Gamma频段和高Gamma频段6个频段上分别构建网络,对比分析两组功能连接网络之间的差异。结果胶质瘤患者脑功能连接网络在Alpha频段呈现显著的小世界网络特性;与健康对照组相比较,胶质瘤患者功能连接在低Gamma和高Gamma频段出现显著下降(P<0.05),左侧半球胶质瘤在beta频段脑功能连接显著高于右侧(P<0.05),而性别、年龄对脑功能连接的影响并无统计学意义。结论胶质瘤患者大脑小世界网络特性出现改变;同时胶质瘤患者在低Gamma和高Gamma频段出现功能连接显著下降,左右大脑半球胶质瘤对患者Beta频段功能连接网络的影响有显著差异。 Objective Our study aims to assess the effects of functional connectivity of Glioma by resting-state MEG. Methods Resting-state MEG data were collected from 20 Glioma patients and 20 healthy control subjects. The Phase Lag Index(PLI) was computed to assess functional connectivity in Delta band (1-4Hz), Theta band (4-8Hz), Alpha band (8-12Hz), Beta band (12-30Hz), low Gamma band (30-45Hz) and high Gamma-band (55-70Hz) after 2LOGN threshold of functional connectivity network of sparse, and the network characteristics such as cluster coefficient C and path length L was measured. We analyzed the differences between the functional connectivity networks using Mann - Whitney U test. Results Functional connectivity network of Glioma patients showed the "small-world" network characteristics in Alpha band. Compared with the functional connectivity of healthy controls'brains, Glioma brains ' functional connectivity, as displayed, decreased significantly (P〈0.05) in low and high Gamma band; As shown in the beta band, Glioma brains'functional connectivity in the left hemisphere was significantly higher than the one in the right side (P〈0.05) ; but gender and sex did not play an important role on brain networks statistically. Conclusion The"small-world" network characteristics was changed in glioma brain network. Compared with healthy subjects, functional connectivity in glioma patients decreased significantly at low and high Gamma frequency; The impact on Beta Band functional connectivity network was different between left and right cerebral hemisphere of glioma brains.
出处 《立体定向和功能性神经外科杂志》 2011年第6期326-330,共5页 Chinese Journal of Stereotactic and Functional Neurosurgery
基金 国家自然科学基金项目(编号:81101112) 江苏省卫生厅资助项目(编号:H200967)
关键词 胶质瘤 静息态脑磁图 小世界网络 相位延迟指数 Glioma Resting-state MEG "Small world"networks Phase Lag Index(PLI)
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  • 1Bullmore E,Sporns O.Complex brain networks:graphtheoretical analysis of structural and functional systems[J].Nat Rev Neurosci,2009,10:186~198.
  • 2Netoff TI,Clewley R,Arno S,et al.Epilepsy in small-world networks[J].J Neurosci,2004,24:8075~8083.
  • 3Stam CJ,de Haan W,Daffertshofer A,et al.Graphtheoretical analysis of magnetoencephalographic function-al connectivity in Alzheimer's disease[J].Brain,2009,132:213~224.
  • 4Bosboom JL,Stoffers D,Wolters E,et al.MEG restingstate functional connectivity in Parkinson's disease relateddementia[J].J Neural Transm,2009,116:193~202.
  • 5Stam CJ,Reijneveld JC.Graph theoretical analysis ofcomplex networks in the brain[J].Nonlinear BiomedPhys,2007,1:3.
  • 6Srinivasan R,Winter WR,Ding J,et al.EEG and MEGcoherence:measures of functional connectivity at distinctspatial scales of neocortical dynamics[J].J NeurosciMethods,2007,166:41~52.
  • 7Watts DJ,Strogatz SH.Collective dynamics of'small-world'networks[J].Nature,1998,393:440~442.
  • 8Stam CJ.Functional connectivity patterns of human mag-netoencephalographic recordings:a'small-world'net-work[J].Neurosci Lett,2004,355:25~28.
  • 9Douw L,Schoonheim MM,Landi D,et al.Cognition isrelated to resting-state small-world network topology:an magnetoencephalographic study[J].Neuroscience,2011,175:169~177.
  • 10Ponten SC,Bartolomei F,Stam CJ.Small-world net-works and epilepsy:graph theoretical analysis of intrac-erebrally recorded mesial temporal lobe seizures[J].Clin Neurophysiol,2007,118:918~927.

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