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异基因免疫治疗促进移植物抗肿瘤效应的探讨 被引量：2

Controversies on the allogeneic immunotherapy to optimize the graft-versus-tumor effect
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摘要 造血干细胞移植后绌胞免疫缺陷是疾病复发的一个重要原因，同时异基因造血干细胞移植也可以认为是一种过继性免疫治疗，能克服受者细胞免疫缺陷和促进移植物抗肿瘤（GVT）效应，清除微小残留病和预防疾病复发。如何提高GVT效应仍需要进一步明确，重点介绍2011年美国血液学会（ASH）年会上相关的新进展。 Cellular immunodeficiency is malignancy post stem cell transplantation. On the an important factor related to relapse of hematological other hand, allogeneic stem cell transplantation can be considered the adoptive immunotherapy, which can overcome the host immunodeficiency and promote graft- versus-tumor （GVT） effect for elimination of minimal residual disease and prevention of relapse. How to optimize the GVT induction is required to be defined more clearly. In this review, advance knowledge concerning the optimized and clinical setting of GVT induction from 2011 ASH annual meeting is summarized.
作者 李扬秋
机构地区 暨南大学医学院血液病研究所再生医学教育部重点实验室
出处 《白血病．淋巴瘤》 CAS 2012年第1期3-5,12,共4页 Journal of Leukemia & Lymphoma
关键词 造血干细胞移植 异基因 移植物抗肿瘤 免疫疗法 过继 Hematopoietic stem cell transplantation, allogeneic Graft versus tumor Immunotherapy, adoptive
分类号 R730.5 [医药卫生—肿瘤]
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参考文献8

  • 1Porter DL. Allogeneic immunotherapy to optimize the graft-versustumor effect: concepts and controversies. Hematology Am Soc Hematol Educ Program,2001,2011:292-298.
  • 2Dennis M,Goodyea O,Loke J,et al.Azacitidine induces expansion of regulatory T cells and tumour specific CD +8 T lymphocytes after allogeneic stem cell transplantation: a strategy for epigenetic manipulation of a graft-versus-leukemia response. 2011 ASH Annual Meeting,Abstract 324.
  • 3Schuster S J,Hosing CM,Shpall EJ,et al.Adoptive immunotherapy with autologous CD3/CD28-costimulated T-cells after fludarabine-based chemotherapy in patients with chronic lymphocytic leukemia. 2011ASH Annual Meeting,Abstract 2855.
  • 4Zhang M,Sukhumalchandra P,Enyenihi AA,et al.A novel HLA-A2 restricted peptide derived from cathepsing is an effective immunotherapeutic target for myeloid leukemia. 2011 ASH Annual Meeting,Abstract 2986.
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  • 7Hudecek M,Lupo-Stanghellini MT,Kosasih P,et al.Naive CD+4 T cells modified to express a ROR1-specific CAR mediate anti-tumor activity and provide superior help to CD+8 ROR1-CAR T cells. 2011 ASH Annual Meeting,Abstract 643.
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同被引文献54

  • 1Krell PFI, Weber S, Reuther S, et al. Next generation sequencing spectratyping (NGS-S) comprehensively monitors T cell receptor diversity in children with T cell abnormalities. 2011 ASH Meeting:Abstract 2173.
  • 2Brown J, Kim HT, Cutler C, et al. Immune reconstitution after cord blood transplantation in adults depends on activity of thymic epithelial cells and vascular endothelial elements. 2011 ASH Meeting: Abstract 4075.
  • 3Kanda J, Rizzieri DA, Long GD, et al. The impact of lymphocyte subset recovery at 3 months on progression-free survival after myeloablative allogeneic stem cell transplantation. 2011 ASH Meeting: Abstract 4065.
  • 4Jimenez-Zepeda VH, Reece DE, Trudel S, et al. Absolute lymphocyte count as predictor of overall survival for patients with multiple myeloma treated with single autologous stem cell transplant: experience of a single centre. 2011 ASH Meeting:Abstract 4121.
  • 5McGoldrick SM, Guerrero A, Yamamoto TN, et al. Cytomegalovirus- specific T cells are elicited early after umbilical cord blood transplant but fail to expand in vivo and control virus replication. 2011 ASH Meeting:Abstract 1974.
  • 6Kalina T, Krol L, Stuchly J, et al. Dual production of IL-2 and IFN- gamma by CMV-specific CD2 T-cells is a hallmark of their ability to control CMV reactivation in patients after hematopoietic stem cell transplantation. 2011 ASH Meeting:Abstract 4081.
  • 7Bosch M, Dhadda M, Hoegh-Petersen M, et al. Immune reconstitution after antithymocyte globulin (ATG)-conditioned hematopoietic cell transplantation (HCT). 2011 ASH Meeting:Abstract 1981.
  • 8Handgretinger R, Lang P, Feuchtinger TF, et al. Transplantation of TcR ct 13/CDI9 depleted stem cells from haploidentical donors: robust engraftment and rapid immune reconstitution in children with high risk leukemia. 2011 ASH Meeting, Abstract 1005.
  • 9Wailer EK, Harris WAC, Devine S, et al. Larger numbers of donor naive CD 2+ T-cells and plasmacytoid dendritic call precursors in allogeneic BM grafts from unrelated donors are associated with improved survival: resuhs from BMT CTN 0201. 2011 ASH Meeting: Abstract 1004.
  • 10Perruccio K, Ruggeri L, Moretti S, et al. Thymosin alfa 1 administration improves immune reconstitution and decreases infection-related mortality after HLA-matched sibling T cell-depleted stem cell transplantation. 2011 ASH Meeting: Abstract 1013.

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白血病．淋巴瘤
2012年 第1期

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