PET—CT在霍奇金淋巴瘤治疗中的作用

Positron emission tomography in the management of Hodgkin lymphoma

准确的影像学检查对淋巴瘤的优化治疗至关重要。通过提供解剖学和功能学信息，PET-CT从根本上改变了包括霍奇金淋巴瘤在内的淋巴瘤分期、疗效监测与评估以及治疗方法的选择。与标准检查方法联合应用，PET—CT可以提高病变部位检测的敏感性，监测治疗期间疾病的缓解程度，区分纤维坏死性瘢痕组织和有活性的肿瘤组织，提供预后信息。PET—CT已成为现代淋巴瘤治疗不可或缺的一部分，但是作为相对较新的诊断技术，其全部优点和缺点没有完全研究清楚。根据临床试验的最新结果和单中心应用PET-CT的经验，从临床角度探讨PET—CT的优点和缺点。

Accurate imaging of lymphoma is essential for optimal management. Positron emission tomography（PET-CT）, by providing both anatomic and functional information, is fundamentally altering staging, monitoring of response,response assessment,and choice of treatment modality for lymphomas, including Hodgkin lymphoma. This imaging technique, when used carefully in conjunction with standard testing, increases the sensitivity of lesion detection, provides an opportunity to monitor the quality of response during treatment, permits separation of fibronecrotic scartissue from viable tumor, and adds prognostic information. PET-CT has become integral to modern lymphoma management, but as a relatively new diagnostic technique, it is still being studied and neither its full potential nor its major limitations are fully understood. Discussed herein are recent observations from clinical trials and single-center experiences with PET-CT to explore its advantages and limitations from a clinician＇ s point of view.