结外鼻型NK／T细胞淋巴瘤生物学特征和分子生物学研究热点

Biological characteristics and molecular biology research hotspots of extranodal NK/T-cell lymphoma, nasal type

结外鼻型NK／T细胞淋巴瘤（NKTL）是WHO恶性淋巴瘤分类中一种独立的病理类型，由于该病少见，对肿瘤生物学行为的研究相对较少。近几年，建立了系列细胞系和裸鼠模型，为NKTL的分子生物学研究提供了前提，奠定了基础。同时，开展了NKTL肿瘤增殖、肿瘤微环境和基因谱等方面的研究。对近几年NKTL的分子生物学研究热点进行综述，以探索进一步研究方向。

Extranodal NK/T-Cell lymphoma, nasal Type （NKTL） is an individual type in the World Heahh Organization （WHO） classification. The reports for NKTL are relatively uncommon since the incidence of this disease is low. In recent years, the nude mice model and cell lines of NKTL were established which built up the basis of researches in molecular biology. The investigation are carried out in molecular genetic analysis of lymphoproliferative disorders, tumor microenvironment, and target therapy and so on. We reviewed those advances and concentrated on the development of NKTL molecular biology.