^18氟-脱氧葡萄糖正电子发射计算机断层显像寻找未知原发灶肿瘤原发灶的临床价值

Detection of primary sites of unknown primary tumors using lSF-FDG PET-CT t

目的研究”氟一脱氧葡萄糖正电子发射计算机断层显像（^18F－FDGPET－CT）在寻找原发灶不明转移癌（CUP）患者原发灶中的临床价值。方法回顾性分析为寻找原发灶而行^18F-FDGPET．CT扫描的CUP患者48例，其中男28例，女20例；年龄41-82岁，平均（57±16）岁。依据转移癌部位不同将患者分为颈部淋巴结转移组（28例）及非颈部淋巴结转移组（20例），计算并比较^18F-FDGPET-CT诊断各组原发灶的灵敏度。结果^18F-FDGPET-CT寻找CUP患者原发病灶的灵敏度为66．7％（32／48），寻找颈部淋巴结转移CUP患者的灵敏度为78．6％（22／28），非颈部淋巴结转移CUP患者的灵敏度为50．0％（10／20）；^18F-FDGPET-CT诊断颈部淋巴结转移组CUP患者原发灶的灵敏度与非颈部淋巴结转移组相比，差异有统计学意义（x。4．286，P〈0．05）。结论^18F-FDGPET-CT诊断CUP患者原发灶灵敏度较高，尤其适用于颈部淋巴结转移的CUP患者。、

Objective To determine the value of ^18F-FDG PET-CT in detecting the primary origin of cancer of unknown primary （CUP）. Methods A total of 48 patients （age range 41-82 years, mean age of 57±16 years, 20 females） were retrospectively selected. All patients were diagnosed as CUP and were examined by lSF-FDG PET-CT scan. The patients were divided into cervical lymph node metastasis group （28 cases） and extra-cervical lymph node metastasis group （20 cases） according to different metastasis site. Sensitivity of ^18F-FDG PET-CT to detect primary tumor site was compared between these two groups. Results ^18F-FDG PET-CT detected primary tumors in 32 of 48 patients （66.7 %）, the cervical lymph node metastasis tumoi＇s in 22 of 28 patients （78.6 %）, and extra-cervical lymph node metastasis tumors in 10 of 20 patients （50.0 %）. There was significant difference between cervical lymph node metastasis group and extra-cervical lymph node metastasis group （X2 = 4.286, P 〈 0.05）. Conclusion ^18F-FDG PET-CT has a high sensitivity to detect primary Origin of CUP, especially for patients with cervical lymph node metastasis.