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抗血管生成药物在乳腺癌治疗中的现状和思考 被引量：3

Status and thinking on anti-angiogenesis drugs for treatment of breast cancer
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摘要 抗血管生成药物已成为肿瘤治疗的重要手段和研究热点。该类药物如贝伐单抗、舒尼替尼、索拉非尼、拉帕替尼等也被临床用于治疗乳腺癌，显示出一定疗效，同时也带来了一些问题和思考。 Anti-angiogenesis drug has become an important method and a hot research field for treating cancers. Drugs such as bevacizumab, sunitinib, sorafenib, lapatinib, achieved good clinical effect in treating breast cancers, but they also brought a lot of problems that need to be concerned.
作者 赵新 吴世凯 宋三泰
机构地区 解放军总医院 解放军三
出处 《肿瘤研究与临床》 CAS 2012年第2期73-75,83,共4页 Cancer Research and Clinic
关键词 乳腺肿瘤 血管生成抑制剂 Breast neoplasms Angiogenesis inhibitors
分类号 R737.9 [医药卫生—肿瘤]
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参考文献37

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同被引文献41

  • 1范钰,郑树,丁佳逸.脂质体介导的cripto反义寡核苷酸抑制结肠癌细胞端粒酶活性[J].中国病理生理杂志,2006,22(4):762-765. 被引量：42
  • 2郭辉,张玲.乳香中化学成分和药理作用的研究进展[J].食品与药品,2007,9(05A):50-52. 被引量：43
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  • 6Park YS, Lee JH, Harwalkar JA, et al. Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2. Adv Exp Med Biol, 2002, 507: 387-393.
  • 7Syrovets T, Gschwend JE, Buchele B, et al. Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC3 prostate cancer cells in vitro and in vivo. J Biol Chem, 2005,280: 6170-6180.
  • 8Yuan HQ, Kong F, Wang XL, et al. Inhibitory effect of acetyl-11-keto-beta-boswellic acid on androgen receptor by interference of Spl binding activity in prostate cancer cells. Biochem Pharmacol, 2008, 75:2112-2121.
  • 9Liu JJ, Huang B, Hooi SC. Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells. Br J Pharmacol, 2006, 148: 1099-1107.
  • 10Kunnumakkara AB, Nair AS, Sung B, et al. Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. Mol Cancer Res, 2009, 7: 118-128.

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肿瘤研究与临床
2012年 第2期

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