原发性胆囊癌基因诊断现状

Status of gene diagnosis in primary gallbladder carcinoma

原发性胆囊癌（PGC）是胆道系统常见的恶性肿瘤，恶性程度高、预后差。因其临床表现不典型，常与胆囊炎、胆囊结石的症状相似，早期诊断比较困难。而且随着腹腔镜胆囊切除术（Lc）在临床上的普及，术后诊断胆囊癌的病例也逐渐增多。因此，如何提高PGC的早期诊断水平，为其早期治疗创造条件一直是人们所关注的问题。现代医学在基凶学水半上研究PGC的生物学行为，有助于提高其早期诊断率。就近年来国内外有关PGC基凶诊断的研究状况进行综述。

Primary gallbladder carcinoma is a common biliary malignant tumor, with highly malignant, high mortality and poor prognosis.Its atypical clinical manifestation is often associated with cholecystitis and gallstone. Early diagnosis is very difficult. Laparoscopic cholecystectomy in clinical is popularity and cases of postoperative diagnosis of gallbladder cancer are gradually increasing. Therefore, how to improve the diagnosis of early gallbladder cancer, early treatment of gallbladder carcinoma has been to create concerns. Modern medical studies about the gene level and ,he biological behavior of gallbladder cancer, help to improve the early diagnosis of gallbladder cancer. In this article, the recent advances in research the genetic diagnosis of primary gallbladder carcinoma will be summarized.