丁丙诺啡肌注预先镇痛在甲状腺手术后镇痛的应用

Application of preemptive analgesia with intramuscular buprenorphine in postthyroidectomy pain

目的观察丁丙诺啡肌注预先镇痛用于甲状腺手术后镇痛的效果及安全性。方法将甲状腺手术194例随机分为丁丙诺啡预先镇痛组（A组）和对照组（B组）。观察其术后镇痛效果（VAS评分）与不良反应。结果术后各时点A组镇痛效果优于B组（P〈0．01），而恶心呕吐与呼吸抑制无统计学差异（P〉0．05）。结论丁丙诺啡肌注预先镇痛可安全有效地治疗甲状腺手术后的疼痛。

Objective To observe the preemptive analgesic effect and safety with intramuscular injection of buprenorphine for postoperative pain after thyroidectomy. Methods One hundred and ninety-four patients scheduled for thyroidectomy were randomly divided into buprenorphine preemptive analgesia group （Group A, n：96） and control group （Group B, n=98）. Analgesic efficacy was assessed by VAS, and the incidences of postoperate nausea and vomiting（PONV） and respiratory de- pression were also observed after the operation . Results The analgesic efficacy was significantly better in group A than that in Group B （P〈0.01）. There were no significantly differences in the incidences of PONV and respiratory depression between the two groups （P〈0.05）. Conclusion The application of preemptive analgesia with intramuscular injection of buprenorphine is a safe and effective method for the relief of postoperative pain after thyroidectomy.