端粒酶和血管内皮生长因子C与恶性肿瘤关系的研究现状

The Study Status of Telomeres and VEGF-C in Cancer

近年来,随着城市化进程的加快及环境污染的加重,恶性肿瘤逐渐成为我国居民死亡主要病因之一,而在对肿瘤的研究中,端粒酶和血管内皮生长因子C(VEGF-C)成为肿瘤标志物中热门的研究课题之一。端粒酶是一种反转录酶,它的激活能解决染色体末端复制缩短问题,它的过度表达能使细胞永生化并直接导致肿瘤的形成,而VEGF-C可以调节肿瘤血管、淋巴管新生,刺激淋巴管内皮细胞增殖,调节淋巴管内皮细胞分化和淋巴管增生,促进肿瘤细胞进入淋巴管并通过淋巴系统向全身扩散,从而促进肿瘤淋巴道转移。近来关于端粒酶和VEGF-C与恶性肿瘤关系的研究也逐渐深入。

In recent years, the fact that cancer becomes one of the major fatal diseases in China with the accelerated process of urbanization and environmental pollution. In the study of tumor, tclomerase and vascular endothelial growth factor-C （VEGF-C）are becoming one of the hot research topics as tumor markers. Telomerase is a reverse transcriptase, its activation can reduce the problem to solve the ends of chromosomes replicate, and its overexpression can make cells immortal and directly lead to tumor formation, and VEGF-C may regulate tumor angiogenesis, lymph-mediated vascular endothelial cell proliferation, regulation of lymphatic endothelial cell differentiation and proliferation of lymphatic vessels, promoting tumor cell into the lymphatic vessels and spread to the body through the lymphatic system to promote lymph node metastasis. Recently the research about the relationship between telomerase, VEGF-C and cancer is going deeply gradually.