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大剂量维生素C治疗鼻咽癌放疗后期口腔溃疡的临床观察 被引量:10

Clinical Observation on Large Doses of Vitamin C for Treatment of Late Nasopharyngeal Carcinoma Radiotherapy Oral Ulcer
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摘要 目的探讨大剂量维生素C对鼻咽癌放疗后期口腔溃疡的治疗效果。方法选取鼻咽癌放疗后期引起口腔溃疡Ⅱ、Ⅲ、Ⅳ度患者50例,随机分为观察组和对照组。对照组:在放疗期间,给予常规口腔护理,每日餐前餐后,放疗前后定时用蒸馏水/盐水漱口,Ⅳ度口腔溃疡患者加用硼酸溶液漱口,西瓜霜喷剂辅助治疗及营养支持治疗。治疗组:在对照组的基础上加用维生素C 3.0 g/d静脉注射,7 d后比较治疗效果。结果观察组使用大剂量维生素C治疗鼻咽癌放疗后期引起口腔溃疡患者的疗效优于对照组(Z=-5.494,P<0.001)。结论大剂量维生素C对鼻咽癌放疗后期口腔溃疡的治疗有效。 Objective To observe the efficacy and toxicity of high-dose vitamin C on oral ulcers of pa- tients with nasopharyngeal carcinoma caused by post-radiotherapy. Methods 50 patients with nasopharyngeal carcinoma, including Ⅱ , Ⅲ and Ⅳ degree of oral ulcers caused by post-radiotherapy, were randomly divid- ed into treatment group and control group. Control group:during radiotherapy, besides routine oral care, the patients use distilled water or salt water for gargle before radiotherapy and meal and after radiotherapy and meal. Patients with oral ulcers of Ⅳ degree gargle with boric acid, watermelon frost spray adjuvant and nutri- tional support. Treatment group:based on the control group, the patients received vitamin C (3.0g, qd)intravenously. 7 days later, the treatment effect of the two groups were compared. Results The efficiency of treatment group is significant than control group ( Z = - 5. 494, P 〈 0. 001 ). Conclusion High-dose vitamin C on oral ulcers oral ulcers of patients with nasopharyngeal carcinoma caused by post-radiotherapy is effective.
出处 《医学综述》 2012年第5期791-792,共2页 Medical Recapitulate
关键词 大剂量 维生素C 鼻咽癌 放疗 口腔溃疡 Lrge amount Vitamin C Nasopharyngeal carcinoma Radiotherapy Oral ulcer
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