大剂量维生素C治疗鼻咽癌放疗后期口腔溃疡的临床观察

Clinical Observation on Large Doses of Vitamin C for Treatment of Late Nasopharyngeal Carcinoma Radiotherapy Oral Ulcer

目的探讨大剂量维生素C对鼻咽癌放疗后期口腔溃疡的治疗效果。方法选取鼻咽癌放疗后期引起口腔溃疡Ⅱ、Ⅲ、Ⅳ度患者50例,随机分为观察组和对照组。对照组:在放疗期间,给予常规口腔护理,每日餐前餐后,放疗前后定时用蒸馏水/盐水漱口,Ⅳ度口腔溃疡患者加用硼酸溶液漱口,西瓜霜喷剂辅助治疗及营养支持治疗。治疗组:在对照组的基础上加用维生素C 3.0 g/d静脉注射,7 d后比较治疗效果。结果观察组使用大剂量维生素C治疗鼻咽癌放疗后期引起口腔溃疡患者的疗效优于对照组(Z=-5.494,P<0.001)。结论大剂量维生素C对鼻咽癌放疗后期口腔溃疡的治疗有效。

Objective To observe the efficacy and toxicity of high-dose vitamin C on oral ulcers of pa- tients with nasopharyngeal carcinoma caused by post-radiotherapy. Methods 50 patients with nasopharyngeal carcinoma, including Ⅱ , Ⅲ and Ⅳ degree of oral ulcers caused by post-radiotherapy, were randomly divid- ed into treatment group and control group. Control group：during radiotherapy, besides routine oral care, the patients use distilled water or salt water for gargle before radiotherapy and meal and after radiotherapy and meal. Patients with oral ulcers of Ⅳ degree gargle with boric acid, watermelon frost spray adjuvant and nutri- tional support. Treatment group：based on the control group, the patients received vitamin C （3.0g, qd）intravenously. 7 days later, the treatment effect of the two groups were compared. Results The efficiency of treatment group is significant than control group （ Z = - 5. 494, P 〈 0. 001 ）. Conclusion High-dose vitamin C on oral ulcers oral ulcers of patients with nasopharyngeal carcinoma caused by post-radiotherapy is effective.