中药排列组合对抗乙型肝炎病毒耐药性疗效评价

Effect Assessment of Chinese Medicine Permutation and Combination Against Hepatitis B Virus Resistance

目的:观察中药按药效成分排列组合后对乙肝病毒耐药性的临床疗效。方法:按照各单味中药杀灭病毒的主要有效成分,将其成分大致相同者组成一组,本研究选出3小组药作为治疗组用药,将155例患者随机分为治疗组和对照组。治疗组93例用3组中药随机交替排列使用,进行序贯治疗,对照组62例用拉米呋啶。结果:治疗组93例,显效66例,有效26例,无效1例,总有效率98.9%;对照组62例,显效6例,有效51例,无效5例,总有效率91.9%。两组疗效比较有显著性差异,P<0.05。结论:中药排列组合对抗乙肝病毒耐药性有较明显疗效。

Objective ： To observe the efficacy of composition medicine according to the arrangement on drug resistance of hepatitis B virus. Methods ： According to the the main effective ingredients of each single herb , the herbs with similar effects was in a group, this study selected three groups as a treatment, 155 cases were randomly divided into treatment group and control group. The treatment group had 93 examples which were treated with three groups herbs randomly and alternately with arrangement and the sequential treatment. 62 cases of control group were given lamivudine. Results ： In the treatment group,66 cases apparent effective ,26 patients effective, 1 case ineffective, the total effective rate was 98.9%. In the control group,6 cases apparent effective,51 cases effective,5 cases invalid, the total effective was 91.9%. The comparison between two groups was significant,P 〈 0. 05. Conclusion：Chinese medicine permutation and combination has obviously effect on against drug resistance of hepatitis b virus.