中西医结合治疗慢性充血性心力衰竭45例

Clinical Study on Integrated Chinese and Western Medicine Treating Chronic Congestive Heart Failure

目的:观察中西医结合治疗充血性心力衰竭患者的临床疗效及对炎症因子的影响。方法:入选90例慢性心力衰竭患者,随机分为治疗组及对照组,两组均给予西医常规治疗,治疗组加用瓜蒌薤白半夏汤加减方治疗,疗程均为8周,观察心功能的变化及对炎症因子的影响。结果:治疗后NYHA心功能分级改善治疗组总有效率93.33%,对照组总有效率82.22%,两组比较总有效率的差异具有统计学意义(P<0.05);治疗后每搏输出量(SV)、每分输出量(CO)、左室舒张末容积(EDV)、左室收缩末容积(ESV)及射血分数(EF)等心肌收缩力各项指标的改善程度,治疗组比对照组更为显著,具有统计学意义(P<0.05);治疗后炎症因子高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)治疗组较对照组降低更为明显,具有统计学意义(P<0.05)。

Objective ： The clinical efficacy and effects on inflammatory factors of integrated Chinese and Western medicine treating chronic congestive heart failure were observed. Methods ：90 patients with chronic heart failure were selected and randomly divided into treatment group and control group. Both the two groups were treated with routine western medicine, besides the treat- ment group was given modified Gualou Xiebai Banxia Decoction. The treatment course was 8 weeks. The cardiac function changes and the influence on inflammatory factors were observed. Results：After treatment, the efficiency of the NYHA improvement in treatment group was 93.33% ; in the control group, the total efficiency was, 82. 22%. The total effective rate between the tw6 groups was statistical different （ P 〈 0. 05 ） ; improvements of stroke volume after treatment （ SV）, minute volume （ CO）, left ventricular end diastolic volume （EDV）, end systolic volume （ESV）and ejection fraction （EF）and other indicators of myocardial contrac- tility in the treatment group were more significant than those in control group, with statistical significance （ P 〈 0. 05 ） ; after treatment,highsensitivity Creactive protein （hs -CRP）, tumor necrosis factor-α （TNF -α）of the treatment group decreased more significantly than those of the control group, with statistically significant （P 〈 0. 05 ）.