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布托啡诺用于腰硬联合麻醉术后镇痛的临床观察

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摘要 目的观察比较布托啡诺用于下腹部手术后硬膜外镇痛的临床效果和安全性。方法选择择期下腹部手术患者60例,随机分为两组:B组:0.2%罗哌卡因+0.004%布托啡诺+0.9%氯化钠溶液,共100mL;M组:0.2%罗哌卡因+0.004%吗啡+0.9%氯化钠溶液,共100mL。观察术后4h、8h、12h、24h患者的镇痛镇静评分和不良反应。结果 M组视觉模拟镇痛评分与B组无明显差异,镇静程度评分两组虽无统计学意义,但布托啡诺(B)组的评分均高于吗啡(M)组。B组中有2例恶心呕吐,无皮肤瘙痒;M组中有14例恶心呕吐,9例皮肤瘙痒,两组差异有统计学意义(P<0.05)。结论布托啡诺用于下腹部手术后硬膜外镇痛可产生良好的镇痛镇静作用,安全有效但不良反应发生率低,是理想的硬膜外镇痛药物。
作者 杨淑芬
出处 《海峡药学》 2012年第2期180-181,共2页 Strait Pharmaceutical Journal
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