联合检测血清胱抑素C和同型半胱氨酸在2型糖尿病肾病早期诊断中的意义

Significance of combined detection of serum cystatin C and homocysteine in early diagnosis of type 2 diabetic nephropathy

目的探讨联合检测血清胱抑素C(Cys C)和同型半胱氨酸(Hcy)在2型糖尿病肾病早期诊断中的意义。方法将70例2型糖尿病患者按糖尿病肾病诊断标准分为糖尿病肾病组(n=50)与糖尿病无肾损伤组(n=20),选择50例健康人作为正常对照组。同时检测3组患者的肌酐、尿素氮、糖化血红蛋白(GHbA1c)、尿微量清蛋白排泄率(UAER)、Cys C和Hcy。结果糖尿病肾病组患者肌酐、尿素氮、UAER及Cys C水平高于糖尿病无肾损伤组和正常对照组(P<0.05);糖尿病肾病和糖尿病无肾损伤组分别与正常对照组的GHbA1c水平比较,差异有统计学意义(P<0.05)。结论联合检测Cys C和Hcy可作为2型糖尿病肾病患者肾损害早期诊断的重要指标。

Objective To explore the significance of combined detection of serum cystatin C（Cys C） and homocysteine（Hcy） in early diagnosis of type 2 diabetic nephropathy.Methods 70 patients with type 2 diabetes mellitus divided into diabetic nephropathy group（n=50） and diabetes without kidney injury group（n=20） according to the diagnostic criteria for diabetic nephropathy,and 50 healthy people served as normal control group.Serum reatinine,blood urea nitrogen,glycated hemoglobin（GHbA1c）,urinary albumin excretion rate（UAER）,Cys C and Hcy of patients in the three groups were detected simultaneously.Results Levels of serum creatinine,bloos urea nitrogen,UAER and Cys C of patients in diabetic nephropathy group were significantly higher than those in diabetes without kidney injury group and normal control group（P0.05）.Compared levels of GHbA1c of patients in diabetic nephropathy group and diabetes without kidney injury group with those in normal control group,respectively,differences showed statistically significance（P0.05）.Conclusion Combined detection of Cys C and Hcy can serve as an important indicator for early diagnosis of kidney injury in patients with type 2 diabetic nephropathy.