假丝酵母菌属医院感染临床相关因素调查

Clinical related factors of healthcare-associated Candida infection

目的了解某院住院患者假丝酵母菌属感染的临床相关因素。方法回顾性分析该院2008—2009年住院患者中发生假丝酵母菌属感染者的病历资料。结果 2008—2009年共176例患者发生假丝酵母菌属感染,占医院感染总人次的7.73%;发生感染的部位以下呼吸道最多(55.68%),其次为泌尿道(18.75%);感染的菌种主要为白假丝酵母菌和热带假丝酵母菌,分别占58.52%和23.86%。发生假丝酵母菌属感染前的基础疾病以呼吸系统(30.11%)和泌尿系统(21.59%)疾病多见。发生假丝酵母菌属感染患者住院时间、住院费用、病死率均显著长于或高于同期住院患者(P<0.05)。结论对于有假丝酵母菌属感染相关危险因素的患者,应合理使用抗菌药物,严格执行无菌操作,积极治疗原发病;早诊断、早治疗是防治假丝酵母菌属感染的重要措施。

Objective To realize the clinical characteristics of heahhcare-associated Candida infection in a hospital. Methods Case histories of inpatients who were infected with Candida from 2008 to 2009 were analyzed retrospec- tively. Results One hundred and seventy six patients developed Candida infection from 2008 to 2009, which ae counting for 7.73%o of the total healthcar-associated infection; the most common infection site was lower respirato- ry tract （55.68%）, the next was urinary tract （18.75 %） ; the main fungi were Candida albicans and Candida trop icalis, which accounting for 58.52% and 23.86% .respectively. The main underlying diseases before infection were respiratory （30. 11%）and urological diseases （21.59%）. The length of hospital stay, medical expense and mortality of patients infected with Candida were significantly longer or higher than that of the other patients during the same hospitalization period （P〈0. 05）. Conclusion For patients with the risk of Candida infection, it is important to use antimicrobial agents rationally, manipulate sterilely, and treat the primary disease actively; early diagnosis and early treatment is important measure for preventing and controlling the infection of Candida.