动脉灌注化疗治疗32例恶性梗阻性黄疸患者的临床分析

Clinical anaysis of treating malignant obstructive jaundice by arterial infusion chemotherapy in 32 cases

目的探讨胆道支架置入后行动脉灌注化疗治疗恶性梗阻性黄疸的疗效。方法 32例恶性梗阻性黄疸置入胆道支架后,行动脉灌注化疗,观察血清胆红素和转氨酶变化、支架保持通畅时间和患者生存时间。结果支架置入成功率100%;术后1～2周、术后1个月总胆红素(TB)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(AKP)明显下降(P<0.05);6、12、24个月生存率分别为96.88%(31/32)、71.88%(23/32)、40.63%(13/32),平均生存时间16.3个月;3、6、12个月支架保持通畅率分别96.88%(31/32)、93.75%(30/32)、62.5%(20/32),平均15.6个月。结论放置胆道支架后行动脉灌注化疗治疗恶性梗阻性黄疸是安全有效的方法,能提高患者的生存质量及延长生存时间。

Objective To study the efficacy of treating malignant obstructive jaundice through undertaking arterial infusion chemotherapy after biliary stent implantation. Methods To observe the change of serum hilirubin, transaminase, stent＇ s patency and the survival time in 32 patients with malignant obstructive jaundice treated with arterial infusion chemotherapy after billary stent implantation. Results 32 cases were all successfully inserted with stents; in 1-2 weeks and 1 month after operation, total biliruhin（TB）, alanine aminotransferase（ALT） and alkaline phosphatase（AKP） were decreased significantly（P〈0.05） ;the survival rate of 6,12,24 months were respectively 96.88% （31/32） ,71.88% （23/32） and 40.63% （13/32） ; the stent patency rate of 3, 6,12 months were 96.88% （31/32）, 93.75% （30/32） and 62.5% （20/32）, the average survival time was 15.6 months. Conclusion The therapy of treating malignant obstructive jaundice through undertaking arterial infusion chemotherapy after biliary stent implantation is safe and effective,which can improve the patients＇ life quality and prolong the survival time.