生长抑素与泮托拉唑钠治疗重症急性胰腺炎的疗效及对血清炎性因子的影响

Clinical efficacy of somatostatin and pantoprazole sodium for treating severe acute pancrcatitis and their effects on inflammatory cytokines

目的探讨生长抑素联合泮托拉唑钠治疗重症急性胰腺炎(SAP)的疗效及对血清炎性因子的影响。方法将74例SAP患者随机分为对照组和治疗组,每组各37例。在常规治疗基础上,对照组单用泮托拉唑钠,治疗组采用生长抑素和泮托拉唑钠联用。疗程均为7d。比较两组患者的临床指标(腹痛缓解时间、肠道功能恢复时间和撤离呼吸机时间)及血清炎性因子(血清白介素-8、高敏C反应蛋白和肿瘤坏死因子-α)的水平。结果治疗组的腹痛缓解时间、肠道功能恢复时间和撤离呼吸机时间均优于对照组(P<0.01),而血清白介素细胞-8、高敏C反应蛋白和肿瘤坏死因子-α水平低于对照组(P<0.01)。结论生长抑素联合泮托拉唑钠治疗可显著降低SAP患者血清炎性因子水平,并提高临床治疗效果。

Objective To study the clinical efficacy of somatostatin and pantoprazole sodium for treating sever acute pancreatitis（SAP） and their effects on inflammatory cytokines.Methods 74 cases of SAP were randomly divided into the control group and the treatment group,37 cases in each group.Besides routine treatment,the control group recerived pantoprazole sodium and the treatment group was given the combination therapy of somastatin and pantoprazole sodium with the treatment duration of 7 d.The clinical indexes including the alleviation time of abdominal pain,intestinal function recovery time and ventilator withdrawal time,and serum inflammatory cytokines including interleukins-8（IL-8）,high-sensitivity C-reactive protein（Hs-CRP） and tumor necrosis factor-α（TNF-α） were compared between the two groups.Results The alleviation time of abdominal pain,intestinal function recovery time and ventilator withdrawal time in the treatment group were better than those in the control group（P 0.01）.The levels of serum IL-8,Hs-CRP and TNF-αin the treatment group were lower than those in control group（P 0.01）.Conclusion Combination of somatostatin and pantoprazole sodium can significantly decrease serum inflammatory cytokine,and increase clinical efficacy in patients with SAP.