新疆维吾尔族人群高甘油三酯血症与颈动脉粥样硬化的相关性研究

The relationship between hypertriglyceridemia and carotid atherosclerotic in Xinjiang Uygur population

目的探讨新疆巴州地区维吾尔族人群高甘油三酯（triglyceride,TG）血症与颈动脉粥样硬化（carotid atherosclerotic,CAS）及CAS病变严重程度之间的相关性。方法采用病例对照研究,选择2008年1月~2011年10月在我院内科住院并行颈动脉超声检查确诊的维吾尔族CAS患者452例;对照组460例,为同期入院行颈动脉超声检查排除CAS者。对所有纳入对象测定禁食12h后静脉血清TG值及其他生物化学指标,并结合超声检查情况,探讨高TG血症与CAS及CAS病变严重程度的关系。结果 CAS组高TG血症的患病率为41.15%,明显高于对照组的14.13%（P〈0.01）;血TG水平（1.84±0.93）mmol/L显著高于对照组（1.53±0.95）mmol/L（P〈0.01）。多因素Logistic回归分析显示,在校正了年龄、吸烟、高血压、糖尿病、血脂异常等传统危险因素作用后发现,高TG血症是CAS的独立危险因素（OR=2.865,95%CI：2.017~3.831;P=0.001）。CAS组不同病变亚组之间高TG血症患病率及血TG水平比较差异未见明显统计学意义（P〉0.05）。结论高TG血症是新疆巴州地区维族人群CAS发生的独立危险因素。

Objective To determine the relationship between hypertriglyceridemia and the presence and severity of carotid atherosclerotic （CAS）in the Uygur population from Bazhou area in Xinjiang. Methods The study was designed as a casecontrol study. A total of 912 subjects were recruited between Jan 2008 and Oct 2011 in our hospital. The study group consisted of 452 patients with CAS evidenced by carotid ultrasound. The control group（CAS-free）consisted of 460 subjects without history of atherosclerotic disease. Serum triglyceride level and lipid profile, as well as fasting blood glucose,were measured in all patients before the procedure. The association between hypertriglyceridemia and severity of CAS was analyzed also. Results In to- tal, prevalence of hypertriglyceridemia in patients with CAS was higher as compared to those without CAS （41.15% vs. 14.13%, P〈0.01）, the serum triglyceride level patients had CAS was higher as compared to those without CAS （1.84±0.93）mmol/L vs. （1.53±0.95）mmol/L, P〈0.01. In addition, after adjusting for significant confounding factors including age,diabetes, smoking, cholesterol and hypertension by multivariate regression analysis,prevalence of hypertriglyceridemia was an independent risk factor for CAS （0R=2.865,95%CI： 2.017-3.831 ;P=0.001 ）. However, the prevalence of hypertriglyceridemia and serum triglyceride level was not significantly associated with the severity of CAS （P〉0.05）. Conclusion The findings suggest that hypertriglyeeridemia was an independent risk factor for CAS in Uygur population from Bazhou area in Xinjiang.