布地奈德与特布他林治疗支气管哮喘的临床对照研究

The study on the treatment of bronchial asthma inhaled budesonide and terbutaline

目的探讨布地奈德和特布他林联合雾化吸入治疗支气管哮喘的临床优势。方法将确诊为支气管哮喘的90例患者,按随机数字表分为观察组和对照组,对照组在常规治疗的基础上雾化吸入布地奈德,观察组在对照组基础上雾化吸入布地奈德和特布他林,两组均治疗14d,比较两组的临床疗效、症状体征改善时间、症状评分变化情况,利用SPSS16.0进行统计分析。结果布地奈德和特布他林联合雾化吸入组的总有效率为97.78%,单用布地奈德组的总有效率为73.33%,两组总有效率差异具有统计学意义(P<0.01);布地奈德和特布他林联合雾化吸入组的呼吸困难、喘息、咳嗽、啰音、哮鸣音、住院时间分别为(2.1±0.8)、(3.1±1.4)、(5.3±1.7)、(5.1±1.2)、(3.8±1.4)、(5.9±2.1)d,单用布地奈德组分别为(3.4±1.2)、(4.7±1.0)、(7.3±1.6)、(6.9±1.5)、(5.9±1.3)、(9.3±2.6)d,两组各项指标差异具有统计学意义(P<0.01)。结论布地奈德与特布他林联合雾化吸入能快速改善患者症状与体征,且没有明显不良反应,患者依从性好,吸烟患者应适当地增加剂量,推荐作为支气管哮喘的首选给药方法。

Objective To investigate the advantages of the treatment of bronchial asthma inhaled budesonide and terbutaline. Methods 90 bronchial asthma patients were randomly divided into observation group and control group, the control group were given budesonide inhalation on the basis of conventional treatment, observe group were given budesonide and terbutaline on the basis of conventional treatment. Both groups were treated for 14 d,the clinical efficacy, improvement of symptoms and signs of time, changes in symptom scores were compared by using SPSS16.0 for statistical analysis. Results The total effective rate of observation group was 97.78% ,it of the control group was 73.33 %, total effective difference was statistically significant, P〈0.01 ）, the time of breathing difficulties, wheezing, cough, rales, wheezing and hospitalization time was （2.14± 0.8） d, （ 3.1 ± 1.4） d, （ 5.3 ± 1.7） d, （ 5.1±4-1.2 ） d,（3.8±1.4）d,（5.9±2.1）d,alone in the budesonide group was（3.4±1.2）d,（4.7±1.0）d, （7.3±1.6）d,（6.9±1.5）d, （5.9±1.3）d, （9.3±2.6）d,indicators had statistically significant difference in two groups（P〈0.01）. Conclu- sion The method inhaled budesonide combined with terbutaline have rapid improvement of symptoms and signs,and no significant adverse reactions, patient compliance is good, smoking patients should be appropriate to increase the dose,and that is recommended as the preferred delivery method of bronchial asthma in the treatment of bronchial asthma.