法舒地尔治疗蛛网膜下腔出血的疗效观察

Efficacy of fasudil on subarachnoid hemorrhage

目的观察盐酸法舒地尔治疗蛛网膜下腔出血的临床疗效和安全性。方法选择2009年3月至2010年12月收治的经头部CT或腰椎穿刺检查确诊为自发性蛛网膜下腔出血患者80例，随机分为两组：治疗组40例，除常规治疗外给予法舒地尔注射液治疗；对照组40例，给予尼莫地平注射液治疗。结果盐酸法舒地尔和尼莫地平治疗蛛网膜下腔出血后脑血管痉挛治疗均有效，治疗组有效率为92．5％，对照组为77．5％，两组比较差异有统计学意义（P〈0．05）；治疗组较对照组头痛和颈项强直时间明显缩短（P〈0．05）。结论盐酸法舒地尔是一种新型抗脑血管痉挛药物，此药安全、有效，值得，临床推广使用。

Objective To observe the clinical efficacy and safety of fasudil in the treatment of subaraehnoid hemorrhage. Methods Eighty patients with spontaneous subarachnoid hemorrhage con- firmed by cranial CT or lumbar puncture from Mar. 2009 to Dec. 2010 were randomly divided into two groups, treatment group （40 cases） and control group （40 cases）. All the patients in the two groups re- ceived conventional therapy. Patients in the treatment group received injection of fasudil, patients in the control group received injection of nimodipine. Results Both fasudil and nimodipine were effective to treat cerebral vasospasm following subarachnoid hemorrhage, the effective rate of treatment group was 92.5% and was 77.5% in control group, there was significant difference between the two groups （ P 〈 0. 05）. The time of headache and neck stiffness in treatment group was shorter than that in control group （ P 〈 0.05）. Conclusions Fasudil is worth application for its efficiency and safety in treating cerebral vasospasm following subaraehnoid hemorrhage.