红要子烧伤酊的毒理作用及临床应用

Experimental study and clinical work for toxicant effect of Pteroxygonum burn tincture

目的 :探讨中药制剂红要子烧伤酊的毒理作用 ,评价其临床效果及应用前景。方法 :烧伤面积 1%～2 0 %Ⅱ度伤为主的烧伤患者 40例 ,外用烧伤酊与磺胺嘧啶银 (SD Ag)作对照 ,观察用药反应 ,愈合时间。同时选择豚鼠及家兔分别进行烧伤酊的皮肤急性毒性试验 ,皮肤长期毒性试验 ,皮肤刺激试验及皮肤过敏试验。结果 :烧伤酊组与SD Ag组治疗Ⅱ度烧伤有效率均达 10 0 %。在创面反应、愈合时间上统计学处理差异无显著性 (P >0 0 5 )。毒理实验结果表明烧伤酊对皮肤仅有轻微的刺激反应及过敏反应。结论 :红要子烧伤酊是一种副作用小、使用安全可靠的中药类烧伤创面外用药 ,值得进一步推广应用。

Aim:To prove toxicant effect of the traditional chinese pharmaceutical preparation Pteroxygonum Burn Tincture and evaluate its clinical effect. Methods:chose 40 cases of burn patients whose burn wound area reach 1%～20%,mainly second degree burns.Burn tincture and SD Ag as external application were compared in reaction and recovered period.Meanwhile guinea pigs and rabbits were selected separately to carry out skin acute toxicity test and long term toxicity test,skin stimulative test and allergic test.Results: In the group of burn tincture and SD Ag,the effective rate was 100% for treating second degree burns,as for wound reaction,recovered period,there was no difference in statistics( P >0.05) The result of toxicant test indicates that burn tincture has only slightly stimulative reaction and allergy.Conclusion:Burn tincture is a kind of external use Traditional Chinese medicine for burn wound,which is with minor side effects,safety and reliability in use and worth of spreading.