抑癌基因Rb、MTS_1的表达与膀胱癌的预后

Expression of Tumor Suppressor gene Rb,MTS1 and Prognosis of Bladder Cancer

目的 :研究抑癌基因 Rb、MTS1 的表达与膀胱癌的预后。方法 :用 S- P免疫组化法同步检测 6 0例膀胱移行细胞癌抑癌基因 Rb、MTS1的表达 ,观察其与预后的关系。结果 :PRb、p16表达阳性组生存率明显优于阴性组。结论 :PRb与 p16均具有膀胱癌的预后价值 ,而同步检测两者的预后价值优于单一检测。

Objective:To study the relationship between the expression of tumor suppressor gene Rb and MTS1 and prognosis of bladder cancer.Methods:Expression of tumor suppressor gene Rb and MTS1 were determined by S P immunohistochemical method in 60 specimens of transitional cell bladder cancer, and the relation of these two gene expressions to prognosis was studied.Results:The survival rate in positive cases of Rb or MTS1 expression was higher than those of the negative ones.Conclusion:Either pRb or p16 possesses prognostic value in bladder cancer, however combinating the two would be more valuable than either of one alone.